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CLC protein, human

Known as: Charcot-Leyden Crystal Protein, Galectin-10, Lysolecithin Acylhydrolase 
Eosinophil lysophospholipase (142 aa, ~16 kDa) is encoded by the human CLC gene. This protein is involved in phospholipid metabolism.
National Institutes of Health

Related topics

Related topics

7 relations
CLC geneCLC wt AlleleEnzyme GeneEsterase Gene

Papers overview

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Highly Cited
2010
Highly Cited
2010
Design, function, and structure of a monomeric CLC transporter
Channels and transporters of the ClC family cause the transmembrane movement of inorganic anions in service of a variety of… 
Highly Cited
2007
Highly Cited
2007
Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function.
CD4(+)CD25(+)Foxp3(+) regulatory T cells (CD25(+) Treg cells) direct the maintenance of immunological self-tolerance by active… 
Highly Cited
2006
Highly Cited
2006
Barttin modulates trafficking and function of ClC-K channels.
Barttin is an accessory subunit of a subgroup of ClC-type chloride channels expressed in renal and inner ear epithelia. In this… 
2005
2005
Side-dependent inhibition of a prokaryotic ClC by DIDS.
The x-ray structure of the Escherichia coli chloride/proton antiporter ClC-ec1 provides a structural paradigm for the widespread… 
Highly Cited
2004
Highly Cited
2004
Functional analyses of placental protein 13/galectin-13.
Placental protein 13 (PP13) was cloned from human term placenta. As sequence analyses, alignments and computational modelling… 
Highly Cited
2004
Highly Cited
2004
Mechanism of anionic conduction across ClC.
Highly Cited
2004
Highly Cited
2004
Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases.
BACKGROUND ClC-Ka and ClC-Kb, chloride channels participating in renal tubular Cl- transport, require the coexpression of barttin… 
Highly Cited
2003
Highly Cited
2003
Gating the Selectivity Filter in ClC Chloride Channels
ClC channels conduct chloride (Cl–) ions across cell membranes and thereby govern the electrical activity of muscle cells and… 
Highly Cited
2001
Highly Cited
2001
Projection structure of a ClC-type chloride channel at 6.5 Å resolution
Virtually all cells in all eukaryotic organisms express ion channels of the ClC type, the only known molecular family of chloride… 
Highly Cited
1999
Highly Cited
1999
Selective Recognition of Mannose by the Human Eosinophil Charcot-Leyden Crystal Protein (Galectin-10): A Crystallographic Study at 1.8 Å Resolution.
The role(s) of the eosinophil Charcot-Leyden crystal (CLC) protein in eosinophil or basophil function or associated inflammatory… 
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