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CHIR 090
Known as:
CHIR-090
, CHIR090
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (2)
Hydroxamic Acids
Threonine
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Untargeted Metabolomics To Ascertain Antibiotic Modes of Action
Isabel M. Vincent
,
D. Ehmann
,
S. D. Mills
,
M. Perros
,
M. Barrett
Antimicrobial Agents and Chemotherapy
2016
Corpus ID: 26967900
ABSTRACT Deciphering the mode of action (MOA) of new antibiotics discovered through phenotypic screening is of increasing…
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2012
2012
Design and stereoselective synthesis of a C-aryl furanoside as a conformationally constrained CHIR-090 analogue.
Alberto Oddo
,
Ralph Holl
Carbohydrate research
2012
Corpus ID: 25874578
2011
2011
Design and synthesis of potent Gram-negative specific LpxC inhibitors.
U. F. Mansoor
,
D. Vitharana
,
+5 authors
M. A. Siddiqui
Bioorganic & medicinal chemistry letters
2011
Corpus ID: 40769214
2011
2011
Mechanisms Decreasing In Vitro Susceptibility to the LpxC Inhibitor CHIR-090 in the Gram-Negative Pathogen Pseudomonas aeruginosa
Ruth E. Caughlan
,
Adriana K. Jones
,
+8 authors
C. Dean
Antimicrobial Agents and Chemotherapy
2011
Corpus ID: 206714880
ABSTRACT Testing P. aeruginosa efflux pump mutants showed that the LpxC inhibitor CHIR-090 is a substrate for MexAB-OprM, MexCD…
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2011
2011
Structure of the metal-dependent deacetylase LpxC from Yersinia enterocolitica complexed with the potent inhibitor CHIR-090 .
K. E. Cole
,
Samuel G. Gattis
,
Heather D Angell
,
C. Fierke
,
D. Christianson
Biochemistry
2011
Corpus ID: 12711629
The first committed step of lipid A biosynthesis is catalyzed by UDP-(3-O-((R)-3-hydroxymyristoyl))-N-acetylglucosamine…
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2010
2010
Antimicrobial Activity of CHIR-090, an Inhibitor of Lipopolysaccharide Biosynthesis, against the Burkholderia cepacia Complex
Karin Bodewits
,
C. Raetz
,
J. Govan
,
D. Campopiano
Antimicrobial Agents and Chemotherapy
2010
Corpus ID: 121713
A striking characteristic of cystic fibrosis (CF) is susceptibility to life-limiting bacterial infections of the respiratory…
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Review
2008
Review
2008
Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis.
A. Barb
,
P. Zhou
Current pharmaceutical biotechnology
2008
Corpus ID: 6146161
Multi-drug resistant (MDR), pathogenic Gram-negative bacteria pose a serious health threat, and novel antibiotic targets must be…
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Highly Cited
2007
Highly Cited
2007
Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding
A. Barb
,
Ling Jiang
,
C. Raetz
,
P. Zhou
Proceedings of the National Academy of Sciences
2007
Corpus ID: 1816417
The UDP-3-O-(R-3-hydroxyacyl)-N-acetylglucosamine deacetylase LpxC is an essential enzyme of lipid A biosynthesis in Gram…
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Highly Cited
2007
Highly Cited
2007
Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli.
A. Barb
,
Amanda L. McClerren
,
Karnem Snehelatha
,
C. M. Reynolds
,
P. Zhou
,
C. Raetz
Biochemistry
2007
Corpus ID: 2871500
The deacetylation of UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine (UDP-3-O-acyl-GlcNAc) by LpxC is the committed reaction…
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Highly Cited
2005
Highly Cited
2005
A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin.
Amanda L. McClerren
,
Stephanie Endsley
,
+4 authors
C. Raetz
Biochemistry
2005
Corpus ID: 20983019
The zinc-dependent enzyme LpxC catalyzes the deacetylation of UDP-3-O-acyl-GlcNAc, the first committed step of lipid A…
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