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CHIR 090

Known as: CHIR-090, CHIR090 
 
National Institutes of Health

Papers overview

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2016
2016
ABSTRACT Deciphering the mode of action (MOA) of new antibiotics discovered through phenotypic screening is of increasing… Expand
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2012
2012
The UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase (LpxC) is a promising target for the development of novel… Expand
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2011
2011
The first committed step of lipid A biosynthesis is catalyzed by UDP-(3-O-((R)-3-hydroxymyristoyl))-N-acetylglucosamine… Expand
2011
2011
ABSTRACT Testing P. aeruginosa efflux pump mutants showed that the LpxC inhibitor CHIR-090 is a substrate for MexAB-OprM, MexCD… Expand
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2011
2011
Antibiotic resistant hospital acquired infections are on the rise, creating an urgent need for novel bactericidal drugs. Enzymes… Expand
2010
2010
A striking characteristic of cystic fibrosis (CF) is susceptibility to life-limiting bacterial infections of the respiratory… Expand
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Review
2008
Review
2008
  • A. Barb, P. Zhou
  • Current pharmaceutical biotechnology
  • 2008
  • Corpus ID: 6146161
Multi-drug resistant (MDR), pathogenic Gram-negative bacteria pose a serious health threat, and novel antibiotic targets must be… Expand
Highly Cited
2007
Highly Cited
2007
The deacetylation of UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine (UDP-3-O-acyl-GlcNAc) by LpxC is the committed reaction… Expand
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Highly Cited
2007
Highly Cited
2007
The UDP-3-O-(R-3-hydroxyacyl)-N-acetylglucosamine deacetylase LpxC is an essential enzyme of lipid A biosynthesis in Gram… Expand
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Highly Cited
2005
Highly Cited
2005
The zinc-dependent enzyme LpxC catalyzes the deacetylation of UDP-3-O-acyl-GlcNAc, the first committed step of lipid A… Expand