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Background: CHFR is a tumor suppressor that arrests the cell cycle at prophase. Results: CHFR regulates the mitotic checkpoint… Expand BACKGROUND & AIMS
Synchronous colorectal neoplasias (2 or more primary carcinomas identified in the same patient) are caused by… Expand Chfr is a ubiquitin ligase that functions in the mitotic checkpoint by delaying entry into metaphase in response to mitotic… Expand Background: The CpG island methylator phenotype (CIMP), characterised by widespread promoter methylation, is associated with… Expand Tumorigenesis is a consequence of loss of tumor suppressors and activation of oncogenes. Expression of the mitotic checkpoint… Expand Chromosomal instability (CIN) is a cytogenetic hallmark of human cancers. Increasing evidence suggests that impairment of mitotic… Expand Cell-cycle checkpoints controlling the orderly progression through mitosis are frequently disrupted in human cancers. One such… Expand Mitotic checkpoints prevent errors in chromosome segregation that can lead to neoplasia. Therefore, it is notable that gastric… Expand Chfr, a mitotic stress checkpoint gene, regulates a prophase delay in cells exposed to agents that disrupt microtubules, such as… Expand We used hierarchical clustering to examine gene expression profiles generated by serial analysis of gene expression (SAGE) in a… Expand