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CHFR gene

Known as: CHECKPOINT PROTEIN WITH FHA AND RING FINGER DOMAINS, FLJ10796, CHFR 
This gene is involved in the mitotic checkpoint.
National Institutes of Health

Related topics

Related topics

2 relations
Cell Cycle CheckpointsUbiquitination

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Aggregated Low-Density Lipoprotein Induces LRP1 Stabilization Through E3 Ubiquitin Ligase CHFR Downregulation in Human Vascular Smooth Muscle Cells
Objective—Low density lipoprotein retention and aggregation in the arterial intima are key processes in atherogenesis. Aggregated… 
2011
2011
The Auto-ubiquitylation of E3 Ubiquitin-protein Ligase Chfr at G2 Phase Is Required for Accumulation of Polo-like Kinase 1 and Mitotic Entry in Mammalian Cells*
The E3 ubiquitin-protein ligase Chfr is a mitotic stress checkpoint protein that delays mitotic entry in response to microtubule… 
2010
2010
Epigenetic and genetic silencing of CHFR in esophageal adenocarcinomas
The checkpoint with forkhead‐associated domain and RING‐finger domain (CHFR) is a mitotic checkpoint protein with tumor… 
2007
2007
Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis.
2007
2007
Epigenetic inactivation of the CHFR gene in cervical cancer contributes to sensitivity to taxanes.
A relationship between inactivation of mitotic checkpoint genes and sensitivity of cancer cells to anticancer agents has been… 
2006
2006
Aberrant hypermethylation of the promoter region of the CHFR gene is rare in primary breast cancer
SummaryTaxanes are among the most active agents and they are now known to be an indispensable component in chemotherapy for… 
2005
2005
Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtubule inhibitors
Alterations in the function of cell cycle checkpoints are frequently detected in oral squamous cell carcinomas (OSCCs), and are… 
2005
2005
Aberrant methylation of the CHFR gene in advanced hepatocellular carcinoma.
BACKGROUND/AIMS Recently, aberrant methylation of the CHFR gene associated with gene silencing has been reported in several… 
2004
2004
Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer
Highly Cited
2003
Highly Cited
2003
Promotion of mitosis by activated protein kinase B after DNA damage involves polo-like kinase 1 and checkpoint protein CHFR.
The role of the protein kinase B (PKB/Akt) in the regulation of cell survival and proliferation is well established. PKB is a key… 
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