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CGP 39393

Known as: CGP-39393 
National Institutes of Health

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1 relation

Broader (1)

desirudin

Papers overview

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2004
2004
Influence of piroxicam coadministration on pharmacodynamic parameters and the plasma concentration/effect relationship of recombinant hirudin (CGP 39393)
Recombinant hirudins are currently under investigation for use in myocardial infarction and unstable angina. In this study the… 
1996
1996
Trials and tribulations of thrombin inhibition.
Trials and tribulations of thrombin inhibition Thrombin is a central component in the molecular and cellular response to plaque… 
1995
1995
Effects of Two Different Doses of Hirudin on APTT, Determined with Eight Different Reagents
Summary The APTT has been considered the most suitable candidate to monitor the anticoagulant activity of hirudin. However, its… 
Review
1994
Review
1994
Weak allergenicity of recombinant hirudin CGP 39393 (REVASC) in immunocompetent volunteers. The European Hirudin in Thrombosis Group (HIT Group).
BACKGROUND As a result of their polypeptidic nature, hirudins could theoretically elicit an immunologic response in humans… 
1994
1994
Open Study of Intravenous Recombinant Hirudin (CGP 39393) on Platelet Function and Coagulation in Healthy Volunteers
SummaryTen healthy male volunteers not previously exposed to hirudin participated in an open trial to evaluate the effects on… 
1994
1994
Evaluation of CGP 39393 as the anticoagulant in cardiopulmonary bypass operation in a dog model.
1991
1991
The effects of recombinant desulphatohirudin on arterial thrombosis in rats.
The role of thrombin in the formation of arterial thrombi is poorly understood. With the new availability of the specific… 
1991
1991
The effect of recombinant desulphatohirudin (CGP 39393) on restenosis following experimental balloon angioplasty
Highly Cited
1989
Highly Cited
1989
Recombinant Desulphatohirudin (CGP 39393) Anticoagulant and Antithrombotic Properties In Vivo
Summary The effects of the newly available biotechnology product, recombinant desulphatohirudin (CGP 39393) have been… 
Review
1989
Review
1989
Biology of Recombinant Hirudin (CGP 39393): A New Prospect in the Treatment of Thrombosis
Thrombin plays a central role in activation of the blood coagulation system and is also a potent activator of blood platelets… 
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