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CERS5 wt Allele

Known as: Trh4, FLJ25304, Ceramide Synthase 5 wt Allele 
Human CERS5 wild-type allele is located in the vicinity of 12q13.12 and is approximately 38 kb in length. This allele, which encodes ceramide… Expand
National Institutes of Health

Related topics

Related topics

2 relations
ApoptosisPositive Regulation of Apoptosis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
[Investigating the role of ceramide metabolism-associated CERS5 (LASS5) gene in atherosclerosis pathogenesis in endothelial cells].
OBJECTIVE Ceramide, the backbone of sphingolipids, is the key component affecting atherosclerotic changes through its important… Expand
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2016
2016
LASS5 Interacts with SDHB and Synergistically Represses p53 and p21 Activity.
Longevity Assurance 5 (LASS5), a member of the LASS/Ceramide Synthases family, synthesizes C16-ceramide and is implicated in… Expand
Review
2015
Review
2015
Alternative Antigen Processing for MHC Class I: Multiple Roads Lead to Rome
The well described conventional antigen-processing pathway is accountable for most peptides that end up in MHC class I molecules… Expand
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2011
2011
Peptide transporter TAP mediates between competing antigen sources generating distinct surface MHC class I peptide repertoires
We recently described a category of TAP‐independent peptide‐epitopes that are selectively presented by cells with processing… Expand
2011
2011
D,L-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (DL-PDMP) increases endoplasmic reticulum stress, autophagy and apoptosis accompanying ceramide accumulation via ceramide synthase 5 protein…
In A549 cells, the addition of D,L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (DL-PDMP) led to marked autophagy with… Expand
Highly Cited
2006
Highly Cited
2006
Necessary Role for the Lag1p Motif in (Dihydro)ceramide Synthase Activity*
Lag1 (longevity assurance gene 1) homologues, a family of transmembrane proteins found in all eukaryotes, have been shown to be… Expand
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Highly Cited
2005
Highly Cited
2005
Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.
The Lass (longevity-assurance homologue) family members, which are highly conserved among eukaryotes, function in ceramide… Expand
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Highly Cited
2005
Highly Cited
2005
LASS5 Is a Bona Fide Dihydroceramide Synthase That Selectively Utilizes Palmitoyl-CoA as Acyl Donor*
We demonstrated recently (Riebeling, C., Allegood, J.C., Wang, E., Merrill, A. H. Jr., and Futerman, A. H. (2003) J. Biol. Chem… Expand
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2005
2005
LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia Published, JLR Papers in Press, March 16, 2005. DOI 10.1194/jlr.M500001-JLR200
Ceramide is a key bioactive mediator that inhibits surfactant phosphatidylcholine (PtdCho) synthesis in lung epithelia. Ceramide… Expand
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2005
2005
LASS6, an additional member of the longevity assurance gene family.
Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family. Five mammalian homologs have been reported… Expand
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