Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

CERS5 wt Allele

Known as: Trh4, FLJ25304, Ceramide Synthase 5 wt Allele 
Human CERS5 wild-type allele is located in the vicinity of 12q13.12 and is approximately 38 kb in length. This allele, which encodes ceramide… Expand
National Institutes of Health

Related topics

Related topics

2 relations
ApoptosisPositive Regulation of Apoptosis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
LASS5 Interacts with SDHB and Synergistically Represses p53 and p21 Activity.
Longevity Assurance 5 (LASS5), a member of the LASS/Ceramide Synthases family, synthesizes C16-ceramide and is implicated in… Expand
Is this relevant?
2016
2016
[Investigating the role of ceramide metabolism-associated CERS5 (LASS5) gene in atherosclerosis pathogenesis in endothelial cells].
OBJECTIVE Ceramide, the backbone of sphingolipids, is the key component affecting atherosclerotic changes through its important… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 6
  • figure 4
Is this relevant?
Review
2015
Review
2015
Alternative Antigen Processing for MHC Class I: Multiple Roads Lead to Rome
The well described conventional antigen-processing pathway is accountable for most peptides that end up in MHC class I molecules… Expand
  • figure 1
  • table 1
  • figure 2
Is this relevant?
2011
2011
Peptide transporter TAP mediates between competing antigen sources generating distinct surface MHC class I peptide repertoires.
We recently described a category of TAP-independent peptide-epitopes that are selectively presented by cells with processing… Expand
  • figure 1
  • figure 2
  • figure 4
  • figure 3
  • figure 5
Is this relevant?
2011
2011
D,L-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (DL-PDMP) increases endoplasmic reticulum stress, autophagy and apoptosis accompanying ceramide accumulation via ceramide synthase 5 protein…
In A549 cells, the addition of D,L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (DL-PDMP) led to marked autophagy with… Expand
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Necessary Role for the Lag1p Motif in (Dihydro)ceramide Synthase Activity*
Lag1 (longevity assurance gene 1) homologues, a family of transmembrane proteins found in all eukaryotes, have been shown to be… Expand
  • table 2
  • table 1
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.
The Lass (longevity-assurance homologue) family members, which are highly conserved among eukaryotes, function in ceramide… Expand
  • table 1
  • figure 1
  • figure 3
  • figure 2
  • figure 4
Is this relevant?
Highly Cited
2005
Highly Cited
2005
LASS5 Is a Bona Fide Dihydroceramide Synthase That Selectively Utilizes Palmitoyl-CoA as Acyl Donor*
We demonstrated recently (Riebeling, C., Allegood, J.C., Wang, E., Merrill, A. H. Jr., and Futerman, A. H. (2003) J. Biol. Chem… Expand
Is this relevant?
2005
2005
LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia Published, JLR Papers in Press, March 16, 2005. DOI 10.1194/jlr.M500001-JLR200
Ceramide is a key bioactive mediator that inhibits surfactant phosphatidylcholine (PtdCho) synthesis in lung epithelia. Ceramide… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2005
2005
LASS6, an additional member of the longevity assurance gene family.
Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family. Five mammalian homologs have been reported… Expand
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE