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CERS1 gene

Known as: CERAMIDE SYNTHASE 1, LASS1, UOG1 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Genes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma
Ceramide synthase 1 (CERS1) is the most highly expressed CERS in the central nervous system, and ceramide with an 18-carbon… 
2014
2014
New insights into the organ-specific adverse effects of fumonisin B1: comparison between lung and liver
Fumonisin B1 (FB1) is a well-known inhibitor of de novo sphingolipid biosynthesis, due to its ability to inhibit ceramide… 
Highly Cited
2012
Highly Cited
2012
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy
Mechanisms by which autophagy promotes cell survival or death are unclear. We provide evidence that C18-pyridinium ceramide (C18… 
Highly Cited
2012
Highly Cited
2012
Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells
Histone deacetylases (HDACs) and microRNAs (miRs) have pro‐survival roles, but the mechanism behind this is unclear. Repression… 
Highly Cited
2012
Highly Cited
2012
CLN5 and CLN8 protein association with ceramide synthase: Biochemical and proteomic approaches
Four patients with juvenile neuronal ceroid lipofuscinoses, a childhood neurodegenerative disorder that was previously described… 
Highly Cited
2010
Highly Cited
2010
HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging
The search for longevity‐determining genes in human has largely neglected the operation of genetic interactions. We have… 
Highly Cited
2008
Highly Cited
2008
Differential expression of (dihydro)ceramide synthases in mouse brain: oligodendrocyte-specific expression of CerS2/Lass2
Synthesis of dihydroceramide is catalyzed by a family of (dihydro)ceramide synthases (CerS), first identified in yeast as… 
Highly Cited
2006
Highly Cited
2006
The CLN9 Protein, a Regulator of Dihydroceramide Synthase*
A new variant of a group of pediatric neurodegenerative diseases known as neuronal ceroid lipofuscinosis (NCL) or Batten disease… 
Highly Cited
2005
Highly Cited
2005
Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.
The Lass (longevity-assurance homologue) family members, which are highly conserved among eukaryotes, function in ceramide… 
Highly Cited
2004
Highly Cited
2004
Differential Regulation of Ceramide Synthase Components LAC1 and LAG1 in Saccharomyces cerevisiae
ABSTRACT In Saccharomyces cerevisiae, the essential ceramide synthase reaction requires the presence of one of a homologous pair… 
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