Empagliflozin, a novel selective sodium glucose cotransporter‐2 (SGLT‐2) inhibitor: characterisation and comparison with other SGLT‐2 inhibitors
- R. Grempler, L. Thomas, P. Eickelmann
- Chemistry, MedicineDiabetes, obesity and metabolism
- 1 January 2012
This study assessed pharmacological properties of empagliflozin in vitro and pharmacokinetic properties in vivo and compared its potency and selectivity with other SGLT‐2 inhibitors.
Mice Deficient in the Polysialyltransferase ST8SiaIV/PST-1 Allow Discrimination of the Roles of Neural Cell Adhesion Molecule Protein and Polysialic Acid in Neural Development and Synaptic Plasticity
- M. Eckhardt, O. Bukalo, Alexander E Dityatev
- BiologyJournal of Neuroscience
- 15 July 2000
An essential role for ST8SiaIV in synaptic plasticity in hippocampal CA1 synapses is demonstrated, whereas PSA produced by different polysialyltransferase or polysIALyltransferases at early stages of differentiation regulates migration of neural precursor cells and correct lamination of mossy fibers.
(R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a Novel Xanthine-Based Dipeptidyl Peptidase 4 Inhibitor, Has a Superior…
- L. Thomas, M. Eckhardt, Elke. Langkopf, M. Tadayyon, F. Himmelsbach, M. Mark
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 April 2008
Investigation of the potency, selectivity, mechanism, and duration of action of BI 1356 in vitro and in vivo and compared it with other DPP-4 inhibitors found it to have the potential to become the first truly once-a-day D PP-4 inhibitor for the treatment of type 2 diabetes.
The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter
- K. Lühn, M. Wild, M. Eckhardt, R. Gerardy-Schahn, D. Vestweber
- BiologyNature Genetics
- 1 May 2001
The first putative GDP-fucose transporter is identified, which has been highly conserved throughout evolution, and a point mutation in its gene is responsible for the disease in this patient with LAD II.
Adult Ceramide Synthase 2 (CERS2)-deficient Mice Exhibit Myelin Sheath Defects, Cerebellar Degeneration, and Hepatocarcinomas*
- Silke Imgrund, D. Hartmann, K. Willecke
- BiologyJournal of Biological Chemistry
- 30 September 2009
The results indicate that CERS2 activity supports different biological functions: maintenance of myelin, stabilization of the cerebellar as well as renal histological architecture, and protection against hepatocarcinomas.
Mutation of FA2H underlies a complicated form of hereditary spastic paraplegia (SPG35)
- K. Dick, M. Eckhardt, A. Crosby
- Medicine, BiologyHuman Mutation
- 1 April 2010
It is demonstrated that mutations in FA2H are associated with SPG35, and that abnormal hydroxylation of myelin galactocerebroside lipid components can lead to a severe progressive phenotype, with a clinical presentation of complicated HSP and radiological features of leukodystrophy.
Membrane Topology of the Mammalian CMP-Sialic Acid Transporter*
- M. Eckhardt, Birgit Gotza, R. Gerardy-Schahn
- BiologyJournal of Biological Chemistry
- 26 March 1999
The functional analysis of the generated mutants demonstrated that insertions in or very close to membrane-spanning regions inactivate the transport process, whereas those in hydrophilic loop structures have no detectable effect on the activity.
Ablation of Neuronal Ceramide Synthase 1 in Mice Decreases Ganglioside Levels and Expression of Myelin-associated Glycoprotein in Oligodendrocytes*
- Christina Ginkel, D. Hartmann, K. Willecke
- Biology, ChemistryJournal of Biological Chemistry
- 16 October 2012
An essential function of CerS1-derived ceramide in the regulation of cerebellar development and neurodevelopmentally regulated behavior in mice is revealed.
The Role and Metabolism of Sulfatide in the Nervous System
- M. Eckhardt
- Biology, ChemistryMolecular Neurobiology
- 9 May 2008
This review summarizes recent studies on the physiological and pathophysiological role of sulfatide using transgenic mice deficient in its synthesis or degradation.
Absence of 2-Hydroxylated Sphingolipids Is Compatible with Normal Neural Development But Causes Late-Onset Axon and Myelin Sheath Degeneration
- Inge Zöller, M. Meixner, M. Eckhardt
- Biology, ChemistryJournal of Neuroscience
- 24 September 2008
Results show that structurally and functionally normal myelin can be formed in the absence of 2-hydroxylated sphingolipids but that its long-term maintenance is strikingly impaired.
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