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CEP 8983

Known as: CEP-8983, CEP8983 
National Institutes of Health

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2 relations

Broader (2)

CarbazolesPhthalimides

Papers overview

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2018
2018
1 PARP INHIBITORS AS P-GLYOPROTEIN SUBSTRATES
The cytotoxicity of PARP inhibitors olaparib, veliparib and CEP-8983 were investigated in two P-glycoprotein overexpressing drug… 
2016
2016
An open-label, dose-escalation study to evaluate the safety and pharmacokinetics of CEP-9722 (a PARP-1 and PARP-2 inhibitor) in combination with gemcitabine and cisplatin in patients with advanced…
Poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors may potentiate chemotherapy by hindering DNA damage repair pathways. CEP-9722… 
Highly Cited
2014
Highly Cited
2014
PARP Inhibitors as P-glyoprotein Substrates.
The cytotoxicity of PARP inhibitors olaparib, veliparib, and CEP-8983 were investigated in two P-glycoprotein (P-gp… 
2014
2014
Poly(ADP-ribose) polymerase inhibitor CEP-8983 synergizes with bendamustine in chronic lymphocytic leukemia cells in vitro.
2013
2013
PARP1 impact on DNA repair of platinum adducts: preclinical and clinical read-outs.
2013
2013
Abstract 3282: Poly (ADP) ribose polymerase (PARP) enzyme inhibitor, CEP8983, potentiates bendamustine activity in small cell lung cancer (SCLC).
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Background: Effective therapy for small cell lung… 
2012
2012
Abstract 3115: PARP overactivation predicts the susceptibility of human cancer cells to apoptosis induction by PARP inhibitors
Chemical inhibitors of poly(ADP)ribose (PAR) polymerases (PARP) have generated raising expectations in cancer treatment, either… 
Highly Cited
2007
Highly Cited
2007
The selective poly(ADP-ribose) polymerase-1(2) inhibitor, CEP-8983, increases the sensitivity of chemoresistant tumor cells to temozolomide and irinotecan but does not potentiate myelotoxicity
The effect of the potent and selective poly(ADP-ribose) (PAR) polymerase-1 [and PAR polymerase-2] inhibitor CEP-8983 on the… 
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