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CEP-1347

Known as: CEP 1347, CEP1347 
National Institutes of Health

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1 relation
KT-7515

Papers overview

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Highly Cited
2007
Highly Cited
2007
Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease
Background: CEP-1347 inhibits mixed lineage kinases that activate apoptotic pathways implicated in the pathogenesis of Parkinson… 
Review
2007
Review
2007
JNK pathway: diseases and therapeutic potential
Abstractc-Jun N-terminal protein kinases (JNK), also known as stress-activated protein kinases, were originally identified by… 
Highly Cited
2005
Highly Cited
2005
Inhibition of microglial inflammation by the MLK inhibitor CEP‐1347
CEP‐1347 is a potent inhibitor of the mixed lineage kinases (MLKs), a distinct family of mitogen‐activated protein kinase kinase… 
2004
2004
Activation of c-Jun N-terminal kinase mediates gp120IIIB- and nucleoside analogue-induced sensory neuron toxicity
Highly Cited
2002
Highly Cited
2002
Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death
Highly Cited
2002
Highly Cited
2002
Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death
Highly Cited
2002
Highly Cited
2002
K252a and CEP1347 Are Neuroprotective Compounds That Inhibit Mixed-lineage Kinase-3 and Induce Activation of Akt and ERK*
K252a is best known as a Trk inhibitor, but is also a neuroprotective compound. CEP1347, a K252a derivative, retains… 
Highly Cited
2001
Highly Cited
2001
CEP‐1347/KT‐7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Aβ‐induced cortical neuron apoptosis
Although the mechanism of neuronal death in Alzheimer's disease (AD) has yet to be elucidated, a putative role for c‐jun in this… 
Highly Cited
2000
Highly Cited
2000
Rescue of Hearing, Auditory Hair Cells, and Neurons by CEP-1347/KT7515, an Inhibitor of c-Jun N-Terminal Kinase Activation
We have studied the mechanisms of auditory hair cell death after insults in vitro and in vivo. We show DNA fragmentation of hair… 
Highly Cited
1999
Highly Cited
1999
CEP‐1347 (KT7515), an Inhibitor of JNK Activation, Rescues Sympathetic Neurons and Neuronally Differentiated PC12 Cells from Death Evoked by three Distinct Insults
The c-Jun N-terminal kinase signaling cascade appears to play a role in some cases of cell death, including neuronal apoptosis… 
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