Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice.
- Cui Li, Dan Xu, Zhiheng Xu
- Biology, MedicineCell Stem Cell
- 7 July 2016
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly
- Ling Yuan, Xingyao Huang, C. Qin
- BiologyScience
- 17 November 2017
A single serine-to-asparagine substitution in the viral polyprotein substantially increased ZIKV infectivity in both human and mouse neural progenitor cells (NPCs) and led to more severe microcephaly in the mouse fetus, as well as higher mortality rates in neonatal mice.
The MLK Family Mediates c-Jun N-Terminal Kinase Activation in Neuronal Apoptosis
- Zhiheng Xu, A. Maroney, P. Dobrzanski, Nickolay V. Kukekov, L. Greene
- BiologyMolecular and Cellular Biology
- 15 July 2001
It is shown that members of the mixed-lineage kinase (MLK) family are expressed in neuronal cells and are likely to act between Rac1/Cdc42 and MKK4 and -7 in death signaling, and findings place the MLKs upstream of mitochondrial cytochromec release and caspase activation.
POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis
- Zhiheng Xu, Nickolay V. Kukekov, L. Greene
- BiologyEMBO Journal
- 15 January 2003
POSH appears to function as a scaffold in a multiprotein complex that links activated Rac1 and downstream elements of the JNK apoptotic cascade, which is required for neuronal death induced by various means including nerve growth factor deprivation.
Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice.
- Cui Li, Dan Xu, Zhiheng Xu
- BiologyCell Stem Cell
- 3 November 2016
β‐Amyloid‐induced neuronal apoptosis requires c‐Jun N‐terminal kinase activation
- C. Troy, S. Rabacchi, L. Greene
- Biology, ChemistryJournal of Neurochemistry
- 1 April 2001
The observations implicate the JNK pathway as a required element in death evoked by Aβ and hence identify it as a potential therapeutic target in AD.
JNK pathway: diseases and therapeutic potential
- Jie Cui, Ming Zhang, Yong-qing Zhang, Zhiheng Xu
- BiologyActa Pharmacologica Sinica
- 1 May 2007
The JNK pathway has been shown to play a major role in apoptosis in many cell death paradigms and its association with a variety of pathological processes is gradually been recognized.
Leucine‐rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin‐like protein
- Jingwen Niu, Mei Yu, Chunyan Wang, Zhiheng Xu
- Chemistry, BiologyJournal of Neurochemistry
- 1 August 2012
J. Neurochem. (2012) 122, 650–658.
Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children.
- K. Nielsen-Saines, P. Brasil, M. E. Moreira
- Medicine, PsychologyNature Network Boston
- 29 May 2019
Nearly one-third of infants born to mothers with confirmed Zika virus (ZIKV) infection during pregnancy have developmental impairments that can be delayed in their presentation, warranting long-term monitoring of ZIKV-exposed children.
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