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CEBPA gene

Known as: C/EBP-alpha, CCAAT/ENHANCER-BINDING PROTEIN, ALPHA, CEBPA 
This gene plays a role in body weight homeostasis and cellular proliferation. Mutations in the gene are associated with acute myeloid leukemia.
National Institutes of Health

Related topics

Related topics

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Acute Myeloid Leukemia with Mutated CEBPACCAAT/Enhancer Binding Protein AlphaCEBPA Gene MutationCEBPA gene full mutation analysis:Prid:Pt:Bone mar:Nar:Molgen
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CEBPA wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Acute myeloid leukemia with biallelic CEBPA gene mutations and normal karyotype represents a distinct genetic entity associated with a favorable clinical outcome.
PURPOSE CEBPA mutations are found as either biallelic (biCEBPA) or monoallelic (moCEBPA). We set out to explore whether the kind… Expand
Highly Cited
2008
Highly Cited
2008
Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia.
BACKGROUND Mutations occur in several genes in cytogenetically normal acute myeloid leukemia (AML) cells: the nucleophosmin gene… Expand
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Highly Cited
2008
Highly Cited
2008
Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer…
PURPOSE To evaluate the prognostic significance of CEBPA mutations in the context of established molecular markers in… Expand
Highly Cited
2005
Highly Cited
2005
Characterization of CEBPA Mutations in Acute Myeloid Leukemia: Most Patients with CEBPA Mutations Have Biallelic Mutations and Show a Distinct Immunophenotype of the Leukemic Cells
Purpose: The transcription factor CCAAT/enhancer binding protein α, encoded by the CEBPA, is crucial for the differentiation of… Expand
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Highly Cited
2004
Highly Cited
2004
CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations.
PURPOSE To assess the prognostic relevance of mutations in the CEBPA gene encoding CCAAT/enhancer binding protein alpha (C/EBP… Expand
Highly Cited
2003
Highly Cited
2003
Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML.
The CCAAT/enhancer binding protein alpha is an essential transcription factor for granulocytic differentiation. Recent studies… Expand
Highly Cited
2003
Highly Cited
2003
Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2
CEBPA encodes the transcription factor C/EBPα and is specifically up‐regulated during granulocytic differentiation. The gene is… Expand
Highly Cited
2002
Highly Cited
2002
Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA).
The transcription factor C/EBPalpha is crucial for differentiation of mature granulocytes. Recently, different CEBPA gene… Expand
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Highly Cited
2001
Highly Cited
2001
Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia.
The transcription factor C/EBPalpha (for CCAAT/enhancer binding protein-alpha; encoded by the gene CEBPA) is crucial for the… Expand
Highly Cited
1990
Highly Cited
1990
IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to CEBP
We analyzed a family of proteins from hepatoma cell nuclei that bind to interleukin-6 responsive elements (IL-6REs) of several… Expand
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