FAQ

CEBPA gene

Known as: C/EBP-alpha, CCAAT/ENHANCER-BINDING PROTEIN, ALPHA, CEBPA 
This gene plays a role in body weight homeostasis and cellular proliferation. Mutations in the gene are associated with acute myeloid leukemia.
National Institutes of Health

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Topic mentions per year

1992-2018
0102019922018

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CCAAT/Enhancer Binding Protein AlphaCEBPA Gene MutationCEBPE geneCEBPE protein, human
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CEBPA wt Allele

Related mentions per year

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1937-2018
19401960198020002020
CEBPA gene
dna binding
Homo sapiens
protein protein interaction
Transcriptional Regulation
CCAAT/Enhancer Binding Protein Alpha

Papers overview

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Highly Cited
2011
Highly Cited
2011
Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double…
We evaluated concurrent gene mutations, clinical outcome, and gene expression signatures of CCAAT/enhancer binding protein alpha… (More)
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Highly Cited
2009
Highly Cited
2009
Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome.
Mutations in CCAAT/enhancer binding protein alpha (CEBPA) are seen in 5% to 14% of acute myeloid leukemia (AML) and have been… (More)
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Highly Cited
2009
Highly Cited
2009
Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis
CCAAT/enhancer binding protein alpha (CEBPA) mutations in AML are associated with favourable prognosis and are divided into N… (More)
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Highly Cited
2005
Highly Cited
2005
Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation.
Adiponectin is secreted from adipocytes, and low circulating levels have been epidemiologically associated with obesity, insulin… (More)
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Highly Cited
2005
Highly Cited
2005
Characterization of CEBPA mutations in acute myeloid leukemia: most patients with CEBPA mutations have biallelic mutations and show a distinct immunophenotype of the leukemic cells.
PURPOSE The transcription factor CCAAT/enhancer binding protein alpha, encoded by the CEBPA, is crucial for the differentiation… (More)
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Highly Cited
2004
Highly Cited
2004
CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations.
PURPOSE To assess the prognostic relevance of mutations in the CEBPA gene encoding CCAAT/enhancer binding protein alpha (C/EBP… (More)
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Highly Cited
2003
Highly Cited
2003
Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML.
The CCAAT/enhancer binding protein alpha is an essential transcription factor for granulocytic differentiation. Recent studies… (More)
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Highly Cited
2002
Highly Cited
2002
Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA).
The transcription factor C/EBPalpha is crucial for differentiation of mature granulocytes. Recently, different CEBPA gene… (More)
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Highly Cited
1998
Highly Cited
1998
CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors.
The transcription factor CCAAT/enhancer binding protein alpha (C/EBPalpha) regulates a number of myeloid cell-specific genes. To… (More)
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Highly Cited
1996
Highly Cited
1996
Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha.
CCAAT/enhancer binding protein alpha (C/EBPalpha) is a transcription factor that has been implicated in the regulation of cell… (More)
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