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CD44 gene

Known as: CD44, chondroitin sulfate proteoglycan 8, IN 
This gene plays a role in cellular matrix adhesion and in lymphocyte activation.
National Institutes of Health

Related topics

Related topics

12 relations
CD44 AntigensCD44 protein, humanCD44 wt AlleleCarbohydrate Metabolism

Papers overview

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2002
2002
Changes in serum hyaluronic acid levels and expression of CD44 and CD44 mRNA in hepatic sinusoidal endothelial cells after major hepatectomy in cirrhotic rats
Serum hyaluronic acid (HA) is widely distributed in connective tissues, and the majority of circulating HA is degraded by hepatic… 
Highly Cited
1998
Highly Cited
1998
Curative treatment of an experimentally induced colitis by a CD44 variant V7-specific antibody.
Inflammatory bowel disease is a quite severe chronic inflammation, treated mainly by immunosuppression, which often has serious… 
Highly Cited
1996
Highly Cited
1996
Requirement for CD44 in proliferation and homing of hematopoietic precursor cells
The hematopoietic form of the adhesion molecule CD44 is known to be involved in lymphocyte maturation and homing. To define… 
Highly Cited
1994
Highly Cited
1994
Hyaluronate is costimulatory for human T cell effector functions and binds to CD44 on activated T cells.
Lymphohematopoiesis, cell matrix adhesion, homing of leukocytes, T cell activation, and tumor metastasis are mediated through the… 
1994
1994
Expression of CD44 splice variants during lymphocyte activation and tumor progression.
Recently, splice variants of CD44 have been described that confer metastatic potential to non-metastasizing rat pancreatic… 
Highly Cited
1993
Highly Cited
1993
Activation of CD44 induces ICAM‐1/LFA‐1‐independent, Ca2+, Mg2+, —independent adhesion pathway in lymphocyte‐endothelial cell interaction
We have established an endothelial cell line KOP2.16 from pooled mouse lymph nodes. Resting lymphocytes avidly bound to KOP2.16… 
1993
1993
Elevation of intracellular cAMP in human T lymphocytes by an anti-CD44 mAb.
Regulation of lymphocyte responses to activation of the CD3/TCR complex by other cell surface proteins expressed on lymphocytes… 
1992
1992
Mechanism of peripheral T cell activation by coengagement of CD44 and CD2.
A number of CD44 antibodies are known to augment peripheral T cell proliferation stimulated with suboptimal concentrations of… 
Highly Cited
1991
Highly Cited
1991
Human T cell activation by OKT3 is inhibited by a monoclonal antibody to CD44.
The CD44 molecule, also known as Hermes lymphocyte homing receptor, human Pgp-1, and extracellular matrix receptor III, has been… 
1990
1990
Murine monoclonal antibody recognizing a 90‐kDa cell‐surface determinant selectively lost by multi‐drug‐resistant variants of cem cells
We describe a murine IgG, monoclonal antibody (MAb56), specific for a cell‐surface protein structure (MC56 determinant) expressed… 
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