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CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?
  • M. Zöller
  • Biology, Medicine
  • Nature Reviews Cancer
  • 1 April 2011
Can an abundantly expressed molecule be a reliable marker for the cancer-initiating cells (CICs; also known as cancer stem cells), which constitute the minority of cells within the mass of a tumour?Expand
Electroweak measurements in electron positron collisions at W-boson-pair energies at LEP
Electroweak measurements performed with data taken at the electron-positron collider LEP at CERN from 1995 to 2000 are reported. The combined data set considered in this report corresponds to a totalExpand
The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments.
TLDR
A method using PCR amplification and primer extension with fluorescent oligonucleotides was developed to analyze T-cell repertoires and shows that beta chains are distributed into at least 2000 groups, a value that provides a lower limit to their complexity. Expand
Tetraspanins: push and pull in suppressing and promoting metastasis
  • M. Zöller
  • Biology, Medicine
  • Nature Reviews Cancer
  • 2009
TLDR
It is reasonable to assume that differences in the membrane and vesicular web components that associate with individual tetraspanins account for their differing abilities to promote and suppress metastasis. Expand
A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells
Using a monoclonal antibody (MAb1.1ASML) raised against a surface glycoprotein of the metastasizing rat pancreatic carcinoma cell line BSp73ASML, cDNA clones have been isolated that encodeExpand
Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
TLDR
EC uptake of Tspan8-CD49d complex-containing exosomes was accompanied by enhanced EC proliferation, migration, sprouting, and maturation of EC progenitors, which could provide new options for therapeutic interference with tumor-induced angiogenesis. Expand
A Complex of EpCAM, Claudin-7, CD44 Variant Isoforms, and Tetraspanins Promotes Colorectal Cancer Progression
TLDR
expression of EpCAM, claudin-7, CO-029, and CD44v6 expression was up-regulated in colon cancer and liver metastasis and coexpression and complex formation of the molecules was correlated with clinical variables and apoptosis resistance. Expand
CD44 in Cancer Progression: Adhesion, Migration and Growth Regulation
TLDR
Through the interplay of CD44 with its ligands and associating molecules CD44 modulates adhesiveness, motility, matrix degradation, proliferation and cell survival, features that together may well allow a tumour cell to proceed through all steps of the metastatic cascade. Expand
Toward tailored exosomes: the exosomal tetraspanin web contributes to target cell selection.
TLDR
This is the first report on the exosomal tetraspanin web contributing to target cell selection such that predictions can be made on potential targets, which will facilitate tailoring exosomes for drug delivery. Expand
Search for heavy neutral and charged leptons in e+e− annihilation at LEP
A search for exotic unstable neutral and charged heavy leptons as well as for stable charged heavy leptons is performed with the L3 detector at LEP. Sequential, vector and mirror natures of heavyExpand
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