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CD276 Antigen

Known as: B7 Homolog 3, B7-H3, 4Ig-B7-H3 
CD276 antigen (534 aa, ~57 kDa) is encoded by the human CD276 gene. This protein is involved in the mediation of T cell proliferation and activation.
National Institutes of Health

Related topics

Related topics

10 relations
CD276 geneCD276 wt AlleleGenes, RegulatorImmune response

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
mTOR and GSK-3 shape the CD4+ T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS.
Prolonged inhibition of the kinase, mammalian target of rapamycin (mTOR), during myeloid dendritic cell (DC) generation confers… 
Highly Cited
2010
Highly Cited
2010
The negative co-signaling molecule b7-h4 is expressed by human bone marrow-derived mesenchymal stem cells and mediates its T-cell modulatory activity.
Though experimental evidence shows that human bone marrow-derived mesenchymal stem cells (hBMSCs) are able to suppress T-cell… 
Highly Cited
2003
Highly Cited
2003
Inducible Costimulatory Molecule-B7-Related Protein 1 Interactions Are Important for the Clonal Expansion and B Cell Helper Functions of Naive, Th1, and Th2 T Cells 1
Inducing T cell responses requires at least two distinct signals: 1) TCR engagement of MHC-peptide and 2) binding of CD28 to B7.1… 
Highly Cited
2000
Highly Cited
2000
CD40-CD40 Ligand-Independent Activation of CD8+ T Cells Can Trigger Allograft Rejection1
In experimental transplantation, blockade of CD40-CD40 ligand (CD40L) interactions has proved effective at permitting long-term… 
Highly Cited
1996
Highly Cited
1996
CD40L is important for induction of, but not response to, costimulatory activity. ICAM-1 as the second costimulatory molecule rapidly up-regulated by CD40L.
The CD40 ligand (CD40L):CD40 interaction plays an important role in the activation of both T and B cells. However, the mechanisms… 
Highly Cited
1995
Highly Cited
1995
Coexpression of B7-1 and viral ("self") transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes.
Highly Cited
1995
Highly Cited
1995
A pathway of costimulation that prevents anergy in CD28- T cells: B7- independent costimulation of CD1-restricted T cells
A class of molecules that is expressed on antigen presenting cells, exemplified by CD80 (B7), has been found to provide a… 
Highly Cited
1994
Highly Cited
1994
The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen.
T-cell activation is initiated after T-cell receptor binding to antigen, but also requires interactions between costimulatory… 
Highly Cited
1994
Highly Cited
1994
In vivo expression of the B7 costimulatory molecule by subsets of antigen-presenting cells and the malignant cells of Hodgkin's disease.
The B-lymphocyte/accessory-cell activation antigen B7 (BB1) has been shown in vitro to stimulate T-lymphocyte proliferation and… 
Highly Cited
1992
Highly Cited
1992
Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex.
We demonstrate that the murine B7 (mB7) protein is a potent costimulatory molecule for the activation of resting murine CD4+ T… 
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