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CCT018159

National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Heterocyclic Compounds, 2-RingPyrazoles

Papers overview

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2016
2016
Potential role of Hsp90 in rat islet function under the condition of high glucose
AimsThe preservation of pancreatic β-cell function is a key point in the treatment of type 2 diabetes mellitus. There is… 
2015
2015
Inhibition of heat shock protein 90 decreases ACTH production and cell proliferation in AtT-20 cells
PurposeCushing’s disease is primarily caused by adrenocorticotropic hormone (ACTH)-producing pituitary adenomas. If excision of… 
2010
2010
Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition
Molecular chaperone heat shock protein 90 (Hsp90) inhibitors are promising targeted cancer therapeutic drugs, with the advantage… 
Highly Cited
2007
Highly Cited
2007
Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues
Although the heat shock protein 90 (HSP90) inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) shows clinical promise… 
Highly Cited
2007
Highly Cited
2007
In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors.
The molecular chaperone heat shock protein 90 (HSP90) has emerged as an exciting molecular target. Derivatives of the natural… 
Highly Cited
2006
Highly Cited
2006
4-Amino derivatives of the Hsp90 inhibitor CCT018159.
2006
2006
Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors
CCT018159 was recently identified as a novel inhibitor of heat shock protein (Hsp) 90, a promising target for cancer therapy… 
2005
2005
Solid-phase immunoassays in mechanism-based drug discovery: their application in the development of inhibitors of the molecular chaperone heat-shock protein 90.
High-throughput screening of chemical libraries and the subsequent rapid progress of hit compounds through an iterative… 
2003
2003
Induction of Hsp70 and depletion of the client protein c-Raf-1 measured by ELISA following cellular exposure to the novel Hsp90 ATPase inhibitor, CCT018159
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