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CB 1954

Known as: CB-1954, CB1954 
National Institutes of Health

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tretazicar

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Highly Cited
2015
Highly Cited
2015
Local bacteria affect the efficacy of chemotherapeutic drugs
In this study, the potential effects of bacteria on the efficacy of frequently used chemotherapies was examined. Bacteria and… Expand
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Review
2004
Review
2004
NAD(P)H:Quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues
NAD(P)H:Quinone Oxidoreductase1 (NQO1) also known as DT-diaphorase is a flavoprotein that catalyzes the two-electron reduction of… Expand
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Highly Cited
2003
Highly Cited
2003
Vectors based on reducible polycations facilitate intracellular release of nucleic acids
Inefficient intracellular delivery of nucleic acids limits the therapeutic usefulness of synthetic vectors such as poly(L‐lysine… Expand
Highly Cited
2003
Highly Cited
2003
Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase
Reactivation of telomerase maintains telomere function and is considered critical to immortalization in most human cancer cells… Expand
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Highly Cited
2001
Highly Cited
2001
Virus-directed, enzyme prodrug therapy with nitroimidazole reductase: a phase I and pharmacokinetic study of its prodrug, CB1954.
CB1954 [5-(aziridin-1-yl)-2,4-dinitrobenzamide] is converted by the bacterial enzyme nitroimidazole reductase (NTR) into a potent… Expand
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Highly Cited
2000
Highly Cited
2000
Prostate-specific antigen promoter/enhancer driven gene therapy for prostate cancer: construction and testing of a tissue-specific adenovirus vector.
A range of luciferase reporter vectors was constructed, incorporating 5'-flanking sequences from the prostate-specific antigen… Expand
Highly Cited
1997
Highly Cited
1997
The bystander effect of the nitroreductase/CB1954 enzyme/prodrug system is due to a cell-permeable metabolite.
The bystander effect is an important part of tumor kill using gene-directed enzyme prodrug therapy (GDEPT). Recently, we have… Expand
Highly Cited
1995
Highly Cited
1995
Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954.
A recombinant retrovirus encoding E. coli nitroreductase (NTR) was used to infect mammalian cells. NIH3T3 cells expressing NTR… Expand
Highly Cited
1992
Highly Cited
1992
The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--I. Purification and properties of a nitroreductase enzyme from Escherichia coli--a potential enzyme for antibody-directed enzyme…
A nitroreductase enzyme has been isolated from Escherichia coli B. This enzyme is an FMN-containing flavoprotein with a molecular… Expand
Highly Cited
1992
Highly Cited
1992
The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase.
A nitroreductase enzyme that has been isolated from Escherichia coli B is capable of bioactivating CB1954 [5-(aziridin-1-yl)-2,4… Expand
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