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CB 1954
Known as:
CB-1954
, CB1954
National Institutes of Health
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Related topics
1 relation
Broader (1)
tretazicar
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives.
R. Singh
,
Sahil Kumar
,
D. Prasad
,
T. Bhardwaj
European journal of medicinal chemistry
2018
Corpus ID: 4811040
Highly Cited
2015
Highly Cited
2015
Local bacteria affect the efficacy of chemotherapeutic drugs
P. Lehouritis
,
Joanne Cummins
,
+6 authors
M. Tangney
Scientific Reports
2015
Corpus ID: 17875857
In this study, the potential effects of bacteria on the efficacy of frequently used chemotherapies was examined. Bacteria and…
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Highly Cited
2003
Highly Cited
2003
Vectors based on reducible polycations facilitate intracellular release of nucleic acids
Martin L Read
,
K. Bremner
,
D. Oupický
,
N. Green
,
P. Searle
,
L. Seymour
Journal of Gene Medicine
2003
Corpus ID: 36706628
Inefficient intracellular delivery of nucleic acids limits the therapeutic usefulness of synthetic vectors such as poly(L‐lysine…
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Highly Cited
2001
Highly Cited
2001
Virus-directed, enzyme prodrug therapy with nitroimidazole reductase: a phase I and pharmacokinetic study of its prodrug, CB1954.
G. Chung-Faye
,
D. Palmer
,
+10 authors
D. Kerr
Clinical Cancer Research
2001
Corpus ID: 7555929
CB1954 [5-(aziridin-1-yl)-2,4-dinitrobenzamide] is converted by the bacterial enzyme nitroimidazole reductase (NTR) into a potent…
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Highly Cited
2000
Highly Cited
2000
Prostate-specific antigen promoter/enhancer driven gene therapy for prostate cancer: construction and testing of a tissue-specific adenovirus vector.
J. Latham
,
P. Searle
,
V. Mautner
,
N. James
Cancer Research
2000
Corpus ID: 43007800
A range of luciferase reporter vectors was constructed, incorporating 5'-flanking sequences from the prostate-specific antigen…
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Highly Cited
1997
Highly Cited
1997
The bystander effect of the nitroreductase/CB1954 enzyme/prodrug system is due to a cell-permeable metabolite.
J. Bridgewater
,
R. Knox
,
J. Pitts
,
M. Collins
,
C. Springer
Human Gene Therapy
1997
Corpus ID: 26922463
The bystander effect is an important part of tumor kill using gene-directed enzyme prodrug therapy (GDEPT). Recently, we have…
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Highly Cited
1995
Highly Cited
1995
Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954.
J. Bridgewater
,
C. Springer
,
R. Knox
,
N. Minton
,
N. Michael
,
M. Collins
European Journal of Cancer
1995
Corpus ID: 29303400
Review
1993
Review
1993
NAD(P)H:Quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues
M. Belinsky
,
A. Jaiswal
Cancer Metastasis Review
1993
Corpus ID: 19806049
NAD(P)H:Quinone Oxidoreductase1 (NQO1) also known as DT-diaphorase is a flavoprotein that catalyzes the two-electron reduction of…
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Highly Cited
1992
Highly Cited
1992
The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--I. Purification and properties of a nitroreductase enzyme from Escherichia coli--a potential enzyme for antibody-directed enzyme…
G. Anlezark
,
R. Melton
,
R. Sherwood
,
B. Coles
,
F. Friedlos
,
R. Knox
Biochemical Pharmacology
1992
Corpus ID: 19572359
Highly Cited
1992
Highly Cited
1992
The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase.
R. Knox
,
F. Friedlos
,
R. Sherwood
,
R. Melton
,
G. Anlezark
Biochemical Pharmacology
1992
Corpus ID: 23486908
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