CB 1954

Known as: CB-1954, CB1954 
 
National Institutes of Health

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2013
2013
Combinatorial Effects of Thymoquinone on the Anticancer Activity and Hepatotoxicity of the Prodrug CB 1954
BACKGROUND One of the major causes of clinical trial termination is the liver toxicity induced by chemotherapeutic agents… (More)
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Highly Cited
2004
Highly Cited
2004
Virus-directed enzyme prodrug therapy: intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer.
PURPOSE Virus-directed enzyme prodrug therapy depends on selective delivery of virus encoding a prodrug-activating enzyme to… (More)
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2003
2003
Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase
Reactivation of telomerase maintains telomere function and is considered critical to immortalization in most human cancer cells… (More)
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Highly Cited
2001
Highly Cited
2001
Inducible ablation of astrocytes shows that these cells are required for neuronal survival in the adult brain.
To study the function of astrocytes in the adult brain, we have targeted the expression of E. coli nitroreductase (NTR) to the… (More)
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2001
2001
Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954
Telomerase activation is considered to be a critical step in cancer progression due to its role in cellular immortalization. The… (More)
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Highly Cited
2000
Highly Cited
2000
Prostate-specific antigen promoter/enhancer driven gene therapy for prostate cancer: construction and testing of a tissue-specific adenovirus vector.
A range of luciferase reporter vectors was constructed, incorporating 5'-flanking sequences from the prostate-specific antigen… (More)
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2000
2000
Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase.
The enzyme nitroreductase from E. coli can reduce the weak, monofunctional alkylating agent 5-(aziridin-1-yl)-2, 4… (More)
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1997
1997
Sensitization of colorectal and pancreatic cancer cell lines to the prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by retroviral transduction and expression of the E. coli nitroreductase…
Expression of genes encoding prodrug-activating enzymes can increase the susceptibility of tumor cells to prodrugs, and may… (More)
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1995
1995
Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954.
A recombinant retrovirus encoding E. coli nitroreductase (NTR) was used to infect mammalian cells. NIH3T3 cells expressing NTR… (More)
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Review
1993
Review
1993
NAD(P)H:Quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues
NAD(P)H:Quinone Oxidoreductase1 (NQO1) also known as DT-diaphorase is a flavoprotein that catalyzes the two-electron reduction of… (More)
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