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CB 1954

Known as: CB-1954, CB1954 
 
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Cancer is considered as one of the most serious health problems today. The discovery of nitrogen mustard as an alkylating agent… Expand
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Review
2004
Review
2004
NAD(P)H:Quinone Oxidoreductase1 (NQO1) also known as DT-diaphorase is a flavoprotein that catalyzes the two-electron reduction of… Expand
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Highly Cited
2003
Highly Cited
2003
Inefficient intracellular delivery of nucleic acids limits the therapeutic usefulness of synthetic vectors such as poly(L‐lysine… Expand
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Highly Cited
2001
Highly Cited
2001
CB1954 [5-(aziridin-1-yl)-2,4-dinitrobenzamide] is converted by the bacterial enzyme nitroimidazole reductase (NTR) into a potent… Expand
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Highly Cited
2000
Highly Cited
2000
A range of luciferase reporter vectors was constructed, incorporating 5'-flanking sequences from the prostate-specific antigen… Expand
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Highly Cited
1997
Highly Cited
1997
The bystander effect is an important part of tumor kill using gene-directed enzyme prodrug therapy (GDEPT). Recently, we have… Expand
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Highly Cited
1997
Highly Cited
1997
Expression of genes encoding prodrug-activating enzymes can increase the susceptibility of tumor cells to prodrugs, and may… Expand
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Highly Cited
1995
Highly Cited
1995
A recombinant retrovirus encoding E. coli nitroreductase (NTR) was used to infect mammalian cells. NIH3T3 cells expressing NTR… Expand
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Highly Cited
1992
Highly Cited
1992
A nitroreductase enzyme has been isolated from Escherichia coli B. This enzyme is an FMN-containing flavoprotein with a molecular… Expand
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Highly Cited
1992
Highly Cited
1992
A nitroreductase enzyme that has been isolated from Escherichia coli B is capable of bioactivating CB1954 [5-(aziridin-1-yl)-2,4… Expand
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