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CB 1954

Known as: CB-1954, CB1954 
National Institutes of Health

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tretazicar

Papers overview

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2017
2017
Evaluation of NfsA-like nitroreductases from Neisseria meningitidis and Bartonella henselae for enzyme-prodrug therapy, targeted cellular ablation, and dinitrotoluene bioremediation
To characterize the activities of two candidate nitroreductases, Neisseria meningitidis NfsA (NfsA_Nm) and Bartonella henselae… 
2015
2015
Mining the HapMap to dissect complex traits
The Keystone Symposium ‘Genome Sequence Variation and the Inherited Basis of Common Disease and Complex Traits’ held in Montana… 
2010
2010
Middleton Mediated Prodrug Cancer Therapy − Quinone Oxidoreductase-2
chemotherapeutic agent. rates of cell division. Thus, the authors propose that a phase II efficacy trial for liver cancer… 
2010
2010
A Computational Investigation of the Mechanism of CB1954 Reduction by E.coli Nitroreductase
The flavoenzyme NTR (nitroreductase nfsB from Escherichia coli) and the prodrug CB1954 (5-[aziridin-1-yl]-2,4-dinitrobenzamide… 
2006
2006
GENE THERAPY FOR TREATMENT OF HIP PROSTHESIS LOOSENING. PRELIMINARY RESULTS OF A PHASE-1 CLINICAL STUDY
Elderly patients with a high mortality risk for revision surgery are severely handicapped by a loosened hip prosthesis. Loosening… 
2005
2005
Virus-directed enzyme prodrug therapy (VDEPT): A clinical trial of adenovirus-delivered nitroreductase (NTR) in combination with CB1954 in patients with primary or secondary liver cancer
3157 Background: The bacterial enzyme nitroreductase (NTR) converts the prodrug CB1954 to a potent bifunctional alkylating agent… 
2005
2005
Studies in NQO2 SNPs and NRH:CB1954 reductase activity in human bladder tumors
Proc Amer Assoc Cancer Res, Volume 46, 2005 1380 NQO2 (NRH:Quinone oxidoreductase 2, EC 1.6.99.-) is a homologue of the… 
2003
2003
A study of the novel VDEPT cancer gene therapy combination nitroreductase / CB1954 : mechanisms of cell death, modulation of cellular signalling pathways and early phase clinical trials.
2000
2000
Prostate-specific Antigen Promoter / Enhancer Driven Gene Therapy for Prostate Cancer : Construction and Testing of a Tissue-specific Adenovirus Vector 1
A range of luciferase reporter vectors was constructed, incorporating 5*-flanking sequences from the prostate-specific antigen… 
1996
1996
Studies on CB1954 and its analogues.
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