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CB 1954

Known as: CB-1954, CB1954 
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
In this study, the potential effects of bacteria on the efficacy of frequently used chemotherapies was examined. Bacteria and… Expand
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Review
2004
Review
2004
NAD(P)H:Quinone Oxidoreductase1 (NQO1) also known as DT-diaphorase is a flavoprotein that catalyzes the two-electron reduction of… Expand
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Highly Cited
2003
Highly Cited
2003
Inefficient intracellular delivery of nucleic acids limits the therapeutic usefulness of synthetic vectors such as poly(L‐lysine… Expand
Highly Cited
2003
Highly Cited
2003
Reactivation of telomerase maintains telomere function and is considered critical to immortalization in most human cancer cells… Expand
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Highly Cited
2001
Highly Cited
2001
CB1954 [5-(aziridin-1-yl)-2,4-dinitrobenzamide] is converted by the bacterial enzyme nitroimidazole reductase (NTR) into a potent… Expand
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Highly Cited
2000
Highly Cited
2000
A range of luciferase reporter vectors was constructed, incorporating 5'-flanking sequences from the prostate-specific antigen… Expand
Highly Cited
1997
Highly Cited
1997
The bystander effect is an important part of tumor kill using gene-directed enzyme prodrug therapy (GDEPT). Recently, we have… Expand
Highly Cited
1995
Highly Cited
1995
A recombinant retrovirus encoding E. coli nitroreductase (NTR) was used to infect mammalian cells. NIH3T3 cells expressing NTR… Expand
Highly Cited
1992
Highly Cited
1992
A nitroreductase enzyme has been isolated from Escherichia coli B. This enzyme is an FMN-containing flavoprotein with a molecular… Expand
Highly Cited
1992
Highly Cited
1992
A nitroreductase enzyme that has been isolated from Escherichia coli B is capable of bioactivating CB1954 [5-(aziridin-1-yl)-2,4… Expand