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tretazicar
Known as:
5-(1-aziridinyl)-2,4-dinitrobenzamide
, 5-aziridinyl-2,4-dinitrobenzamide
, aziridine dinitrobenzamide
A prodrug of a bifunctional alkylating, dinitrobenzamide derivative with antineoplastic activity. Tretazicar can be activated by the human enzyme…
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National Institutes of Health
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Related topics
Related topics
4 relations
Broader (3)
Antineoplastic Agents
Aziridines
Radiation-Sensitizing Agents
Narrower (1)
CB 1954
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
3D Structure, Dimerization Modeling, and Lead Discovery by Ligand‐protein Interaction Analysis of p60 Transcription Regulator Protein (p60TRP)
S. Pramanik
,
Arne Kutzner
,
K. Heese
Molecular Informatics
2016
Corpus ID: 21900752
The p60 transcription regulator protein (p60TRP) is a basic helix‐loop‐helix (bHLH) domain‐containing neuroprotective protein and…
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2002
2002
Bacillus amyloliquefaciens orthologue of Bacillus subtilis ywrO encodes a nitroreductase enzyme which activates the prodrug CB 1954.
G. Anlezark
,
T. Vaughan
,
+6 authors
N. Minton
Microbiology
2002
Corpus ID: 20979778
A nitroreductase with distinct properties that can activate the prodrug 5-aziridinyl-2,4-dinitrobenzamide (CB 1954) was isolated…
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1978
1978
Cyclic nucleotide metabolism in Walker carcinoma cells resistant to alkylating agents.
M. Tisdale
,
B. Phillips
Biochemical Pharmacology
1978
Corpus ID: 29419766
1976
1976
Alterations in adenosine 3', 5'-monophosphate-binding protein in Walker carcinoma cells sensitive or resistant to alkylating agents.
M. Tisdale
,
B. Phillips
Biochemical Pharmacology
1976
Corpus ID: 27062420
1976
1976
The effect of alkylating agents on adenosine 3',5'-monophosphate metabolism in Walker carcinoma.
M. Tisdale
,
B. Phillips
Biochemical Pharmacology
1976
Corpus ID: 30676909
1976
1976
The effect of alkylating agents on the activity of adenosine 3',5'-monophosphate-dependent protein kinase in Walker carcinoma cells.
M. Tisdale
,
B. Phillips
Biochemical Pharmacology
1976
Corpus ID: 43041398
1975
1975
Protection against the effects of the antitumour agent CB 1954 by certain imidazoles and related compounds.
J. Hickman
,
D. Melzack
Biochemical Pharmacology
1975
Corpus ID: 19151288
1972
1972
Studies on the reversal of the selective antitumour effect of the aziridinyl derivative cb 1954 by 4‐amino‐5‐imidazolecarboxamide
T. Connors
,
H. Mandel
,
D. Melzack
International Journal of Cancer
1972
Corpus ID: 44552480
The selective toxicity of CB 1954 (5‐aziridinyl‐2,4‐dinitrobenzamide) for Walker tumour cells, previously shown in the whole…
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1971
1971
Studies on the mechanism of action of 5‐aziridinyl‐2,4‐dinitrobenzamide (CB 1954), a selective inhibitor of the walker tumour
T. Connors
,
D. Melzack
International Journal of Cancer
1971
Corpus ID: 19679905
CB 1954, a monofunctional alkylating agent, has exceptional activity against the Walker carcinoma yet is inactive against a large…
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1971
1971
Cell hybridization study of resistance to alkylating agents.
B. Phillips
,
E. J. Ambrose
Nature: New biology
1971
Corpus ID: 43432280
5-Aziridinyl-2,4-Dinitrobenzamide (CB 1954) has been reported to be a highly selective inhibitor of the Walker tumour, with a…
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