Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

tretazicar

Known as: 5-(1-aziridinyl)-2,4-dinitrobenzamide, 5-aziridinyl-2,4-dinitrobenzamide, aziridine dinitrobenzamide 
A prodrug of a bifunctional alkylating, dinitrobenzamide derivative with antineoplastic activity. Tretazicar can be activated by the human enzyme… Expand
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

Antineoplastic AgentsAziridinesRadiation-Sensitizing Agents

Narrower (1)

CB 1954

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Nitroreductase from Bacillus licheniformis: a stable enzyme for prodrug activation.
5-aziridinyl-2,4-dinitrobenzamide (CB1954) has potential applications in enzyme/prodrug targeted anti-cancer therapies since it… Expand
  • table 1
  • figure 1
  • table 2
  • table 2
  • figure 2
Highly Cited
2008
Highly Cited
2008
Optimized clostridium-directed enzyme prodrug therapy improves the antitumor activity of the novel DNA cross-linking agent PR-104.
We have previously shown that spores of the nonpathogenic clostridial strain C. sporogenes genetically engineered to express the… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
2006
Highly Cited
2006
New enzyme for reductive cancer chemotherapy, YieF, and its improvement by directed evolution
Reductive prodrugs, mitomycin C and 5-aziridinyl-2,4-dinitrobenzamide (CB 1954), are nontoxic in their native form but become… Expand
  • table 1
  • figure 1
  • figure 3
  • figure 2
  • figure 6
2006
2006
Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation.
In efforts to obtain anticancer prodrugs for antibody-directed or gene-directed enzyme prodrug therapy using E. coli… Expand
Highly Cited
2003
Highly Cited
2003
Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of…
The dinitrobenzamide aziridine CB 1954 (1) and its nitrogen mustard analogue SN 23862 (6) are prodrugs that are activated by… Expand
2002
2002
Bacillus amyloliquefaciens orthologue of Bacillus subtilis ywrO encodes a nitroreductase enzyme which activates the prodrug CB 1954.
A nitroreductase with distinct properties that can activate the prodrug 5-aziridinyl-2,4-dinitrobenzamide (CB 1954) was isolated… Expand
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • table 2
1976
1976
Alterations in adenosine 3', 5'-monophosphate-binding protein in Walker carcinoma cells sensitive or resistant to alkylating agents.
Abstract The extent of binding of 8-[ 3 H]adenosine 3′,5′-monophosphate (cyclic AMP) to specific sites was measured in Walker… Expand
1972
1972
Studies on the reversal of the selective antitumour effect of the aziridinyl derivative cb 1954 by 4‐amino‐5‐imidazolecarboxamide
The selective toxicity of CB 1954 (5‐aziridinyl‐2,4‐dinitrobenzamide) for Walker tumour cells, previously shown in the whole… Expand
1971
1971
Tumour-growth inhibitory nitrophenylaziridines and related compounds: structure-activity relationships. II.
  • A. Khan, W. Ross
  • Chemico-biological interactions
  • 1971
    • Corpus ID: 35322114
In Part I of this study it was shown that in a series of substituted 5-(1-aziridinyl)-2,4-dinitrobenzamides, the activity as… Expand
1971
1971
Studies on the mechanism of action of 5‐aziridinyl‐2,4‐dinitrobenzamide (CB 1954), a selective inhibitor of the walker tumour
CB 1954, a monofunctional alkylating agent, has exceptional activity against the Walker carcinoma yet is inactive against a large… Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE