FAQ

tretazicar

Known as: 5-(1-aziridinyl)-2,4-dinitrobenzamide, 5-aziridinyl-2,4-dinitrobenzamide, aziridine dinitrobenzamide 
A prodrug of a bifunctional alkylating, dinitrobenzamide derivative with antineoplastic activity. Tretazicar can be activated by the human enzyme… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1971-2016
01219712016

Related topics

Related topics

4 relations

Broader (3)

Antineoplastic AgentsAziridinesRadiation-Sensitizing Agents

Narrower (1)

CB 1954

Related mentions per year

Related mentions per year

1947-2018
19401960198020002020
tretazicar
Antineoplastic Agents
Radiation-Sensitizing Agents
CB 1954
Aziridines

Papers overview

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2016
2016
3D Structure, Dimerization Modeling, and Lead Discovery by Ligand-protein Interaction Analysis of p60 Transcription Regulator Protein (p60TRP).
The p60 transcription regulator protein (p60TRP) is a basic helix-loop-helix (bHLH) domain-containing neuroprotective protein and… (More)
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2016
2016
Heterologous Overexpression and Biochemical Characterization of a Nitroreductase from Gluconobacter oxydans 621H.
A NADPH-dependent and FMN-containing nitroreductase (Gox0834) from Gluconobacter oxydans was cloned and heterogeneously expressed… (More)
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2009
2009
Nitroreductase from Bacillus licheniformis: a stable enzyme for prodrug activation.
5-aziridinyl-2,4-dinitrobenzamide (CB1954) has potential applications in enzyme/prodrug targeted anti-cancer therapies since it… (More)
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2008
2008
Optimized clostridium-directed enzyme prodrug therapy improves the antitumor activity of the novel DNA cross-linking agent PR-104.
We have previously shown that spores of the nonpathogenic clostridial strain C. sporogenes genetically engineered to express the… (More)
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2008
2008
SALMON: solvent accessibility, ligand binding, and mapping of ligand orientation by NMR spectroscopy.
Quinone oxidoreductase 2 (NQO2) binds the prodrug tretazicar (also known as CB1954, 5-(aziridin-1-yl)-2,4-dinitrobenzamide… (More)
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2006
2006
New enzyme for reductive cancer chemotherapy, YieF, and its improvement by directed evolution.
Reductive prodrugs, mitomycin C and 5-aziridinyl-2,4-dinitrobenzamide (CB 1954), are nontoxic in their native form but become… (More)
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2006
2006
Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation.
In efforts to obtain anticancer prodrugs for antibody-directed or gene-directed enzyme prodrug therapy using E. coli… (More)
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2004
2004
Aziridinyldinitrobenzamides: synthesis and structure-activity relationships for activation by E. coli nitroreductase.
The 5-aziridinyl-2,4-dinitrobenzamide CB 1954 is a substrate for the oxygen-insensitive nitroreductase (NTR) from E. coli and is… (More)
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2002
2002
Bacillus amyloliquefaciens orthologue of Bacillus subtilis ywrO encodes a nitroreductase enzyme which activates the prodrug CB 1954.
A nitroreductase with distinct properties that can activate the prodrug 5-aziridinyl-2,4-dinitrobenzamide (CB 1954) was isolated… (More)
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1971
1971
Studies on the mechanism of action of 5-aziridinyl-2,4-dinitrobenzamide (CB 1954), a selective inhibitor of the Walker tumour.
 
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