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tretazicar

Known as: 5-(1-aziridinyl)-2,4-dinitrobenzamide, 5-aziridinyl-2,4-dinitrobenzamide, aziridine dinitrobenzamide 
A prodrug of a bifunctional alkylating, dinitrobenzamide derivative with antineoplastic activity. Tretazicar can be activated by the human enzyme… 
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
We have previously shown that spores of the nonpathogenic clostridial strain C. sporogenes genetically engineered to express the… 
2006
2006
In efforts to obtain anticancer prodrugs for antibody-directed or gene-directed enzyme prodrug therapy using E. coli… 
Highly Cited
2006
Highly Cited
2006
Reductive prodrugs, mitomycin C and 5-aziridinyl-2,4-dinitrobenzamide (CB 1954), are nontoxic in their native form but become… 
Highly Cited
2003
Highly Cited
2003
The dinitrobenzamide aziridine CB 1954 (1) and its nitrogen mustard analogue SN 23862 (6) are prodrugs that are activated by… 
2002
2002
A nitroreductase with distinct properties that can activate the prodrug 5-aziridinyl-2,4-dinitrobenzamide (CB 1954) was isolated… 
1972
1972
The selective toxicity of CB 1954 (5‐aziridinyl‐2,4‐dinitrobenzamide) for Walker tumour cells, previously shown in the whole… 
1971
1971
CB 1954, a monofunctional alkylating agent, has exceptional activity against the Walker carcinoma yet is inactive against a large…