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tretazicar

Known as: 5-(1-aziridinyl)-2,4-dinitrobenzamide, 5-aziridinyl-2,4-dinitrobenzamide, aziridine dinitrobenzamide 
A prodrug of a bifunctional alkylating, dinitrobenzamide derivative with antineoplastic activity. Tretazicar can be activated by the human enzyme… Expand
National Institutes of Health

Papers overview

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2016
2016
A NADPH-dependent and FMN-containing nitroreductase (Gox0834) from Gluconobacter oxydans was cloned and heterogeneously expressed… Expand
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2009
2009
5-aziridinyl-2,4-dinitrobenzamide (CB1954) has potential applications in enzyme/prodrug targeted anti-cancer therapies since it… Expand
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2008
2008
We have previously shown that spores of the nonpathogenic clostridial strain C. sporogenes genetically engineered to express the… Expand
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2008
2008
Quinone oxidoreductase 2 (NQO2) binds the prodrug tretazicar (also known as CB1954, 5-(aziridin-1-yl)-2,4-dinitrobenzamide… Expand
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2006
2006
Reductive prodrugs, mitomycin C and 5-aziridinyl-2,4-dinitrobenzamide (CB 1954), are nontoxic in their native form but become… Expand
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2006
2006
In efforts to obtain anticancer prodrugs for antibody-directed or gene-directed enzyme prodrug therapy using E. coli… Expand
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2004
2004
The 5-aziridinyl-2,4-dinitrobenzamide CB 1954 is a substrate for the oxygen-insensitive nitroreductase (NTR) from E. coli and is… Expand
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2003
2003
The dinitrobenzamide aziridine CB 1954 (1) and its nitrogen mustard analogue SN 23862 (6) are prodrugs that are activated by… Expand
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2002
2002
A nitroreductase with distinct properties that can activate the prodrug 5-aziridinyl-2,4-dinitrobenzamide (CB 1954) was isolated… Expand
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1971
1971
CB 1954, a monofunctional alkylating agent, has exceptional activity against the Walker carcinoma yet is inactive against a large… Expand
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