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tretazicar

Known as: 5-(1-aziridinyl)-2,4-dinitrobenzamide, 5-aziridinyl-2,4-dinitrobenzamide, aziridine dinitrobenzamide 
A prodrug of a bifunctional alkylating, dinitrobenzamide derivative with antineoplastic activity. Tretazicar can be activated by the human enzyme… Expand
National Institutes of Health

Papers overview

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2009
2009
5-aziridinyl-2,4-dinitrobenzamide (CB1954) has potential applications in enzyme/prodrug targeted anti-cancer therapies since it… Expand
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Highly Cited
2008
Highly Cited
2008
We have previously shown that spores of the nonpathogenic clostridial strain C. sporogenes genetically engineered to express the… Expand
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Highly Cited
2006
Highly Cited
2006
Reductive prodrugs, mitomycin C and 5-aziridinyl-2,4-dinitrobenzamide (CB 1954), are nontoxic in their native form but become… Expand
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2006
2006
In efforts to obtain anticancer prodrugs for antibody-directed or gene-directed enzyme prodrug therapy using E. coli… Expand
Highly Cited
2003
Highly Cited
2003
The dinitrobenzamide aziridine CB 1954 (1) and its nitrogen mustard analogue SN 23862 (6) are prodrugs that are activated by… Expand
2002
2002
A nitroreductase with distinct properties that can activate the prodrug 5-aziridinyl-2,4-dinitrobenzamide (CB 1954) was isolated… Expand
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1976
1976
Abstract The extent of binding of 8-[ 3 H]adenosine 3′,5′-monophosphate (cyclic AMP) to specific sites was measured in Walker… Expand
1972
1972
The selective toxicity of CB 1954 (5‐aziridinyl‐2,4‐dinitrobenzamide) for Walker tumour cells, previously shown in the whole… Expand
1971
1971
  • A. Khan, W. Ross
  • Chemico-biological interactions
  • 1971
  • Corpus ID: 35322114
In Part I of this study it was shown that in a series of substituted 5-(1-aziridinyl)-2,4-dinitrobenzamides, the activity as… Expand
1971
1971
CB 1954, a monofunctional alkylating agent, has exceptional activity against the Walker carcinoma yet is inactive against a large… Expand