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tretazicar
Known as:
5-(1-aziridinyl)-2,4-dinitrobenzamide
, 5-aziridinyl-2,4-dinitrobenzamide
, aziridine dinitrobenzamide
A prodrug of a bifunctional alkylating, dinitrobenzamide derivative with antineoplastic activity. Tretazicar can be activated by the human enzyme…
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National Institutes of Health
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Related topics
Related topics
4 relations
Broader (3)
Antineoplastic Agents
Aziridines
Radiation-Sensitizing Agents
Narrower (1)
CB 1954
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Nitroreductase from Bacillus licheniformis: a stable enzyme for prodrug activation.
Caroline D Emptage
,
R. Knox
,
M. Danson
,
D. Hough
Biochemical Pharmacology
2009
Corpus ID: 19845692
Highly Cited
2008
Highly Cited
2008
Optimized clostridium-directed enzyme prodrug therapy improves the antitumor activity of the novel DNA cross-linking agent PR-104.
Shie-Chau Liu
,
G. Ahn
,
M. Kioi
,
M. Dorie
,
A. Patterson
,
J. Brown
Cancer Research
2008
Corpus ID: 10699707
We have previously shown that spores of the nonpathogenic clostridial strain C. sporogenes genetically engineered to express the…
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2006
2006
Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation.
Yongying Jiang
,
Jiye Han
,
+5 authors
Longqin Hu
Journal of Medicinal Chemistry
2006
Corpus ID: 20943938
In efforts to obtain anticancer prodrugs for antibody-directed or gene-directed enzyme prodrug therapy using E. coli…
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Highly Cited
2006
Highly Cited
2006
New enzyme for reductive cancer chemotherapy, YieF, and its improvement by directed evolution
Y. Barak
,
S. Thorne
,
D. Ackerley
,
S. Lynch
,
C. Contag
,
A. Matin
Molecular Cancer Therapeutics
2006
Corpus ID: 1321018
Reductive prodrugs, mitomycin C and 5-aziridinyl-2,4-dinitrobenzamide (CB 1954), are nontoxic in their native form but become…
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Highly Cited
2003
Highly Cited
2003
Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of…
N. Helsby
,
S. Wheeler
,
+4 authors
W. Wilson
Chemical Research in Toxicology
2003
Corpus ID: 25982429
The dinitrobenzamide aziridine CB 1954 (1) and its nitrogen mustard analogue SN 23862 (6) are prodrugs that are activated by…
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2002
2002
Bacillus amyloliquefaciens orthologue of Bacillus subtilis ywrO encodes a nitroreductase enzyme which activates the prodrug CB 1954.
G. Anlezark
,
T. Vaughan
,
+6 authors
N. Minton
Microbiology
2002
Corpus ID: 20979778
A nitroreductase with distinct properties that can activate the prodrug 5-aziridinyl-2,4-dinitrobenzamide (CB 1954) was isolated…
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1976
1976
Alterations in adenosine 3', 5'-monophosphate-binding protein in Walker carcinoma cells sensitive or resistant to alkylating agents.
M. Tisdale
,
B. Phillips
Biochemical Pharmacology
1976
Corpus ID: 27062420
1972
1972
Studies on the reversal of the selective antitumour effect of the aziridinyl derivative cb 1954 by 4‐amino‐5‐imidazolecarboxamide
T. Connors
,
H. Mandel
,
D. Melzack
International Journal of Cancer
1972
Corpus ID: 44552480
The selective toxicity of CB 1954 (5‐aziridinyl‐2,4‐dinitrobenzamide) for Walker tumour cells, previously shown in the whole…
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1971
1971
Tumour-growth inhibitory nitrophenylaziridines and related compounds: structure-activity relationships. II.
A. H. Khan
,
W. Ross
Chemico-Biological Interactions
1971
Corpus ID: 35322114
1971
1971
Studies on the mechanism of action of 5‐aziridinyl‐2,4‐dinitrobenzamide (CB 1954), a selective inhibitor of the walker tumour
T. Connors
,
D. Melzack
International Journal of Cancer
1971
Corpus ID: 19679905
CB 1954, a monofunctional alkylating agent, has exceptional activity against the Walker carcinoma yet is inactive against a large…
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