CARD9 gene

Known as: CARD9, CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 9, caspase recruitment domain family member 9 
 
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands
Complex interactions between the host and the gut microbiota govern intestinal homeostasis but remain poorly understood. Here we… (More)
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Highly Cited
2014
Highly Cited
2014
Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression
To systematically investigate the impact of immune stimulation upon regulatory variant activity, we exposed primary monocytes… (More)
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Highly Cited
2013
Highly Cited
2013
Deep dermatophytosis and inherited CARD9 deficiency.
BACKGROUND Deep dermatophytosis is a severe and sometimes life-threatening fungal infection caused by dermatophytes. It is… (More)
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Highly Cited
2013
Highly Cited
2013
Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency.
Caspase recruitment domain-containing protein 9 (CARD9) is an adaptor molecule in the cytosol of myeloid cells, required for… (More)
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Highly Cited
2010
Highly Cited
2010
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production
Interleukin 1β (IL-1β) is a potent proinflammatory factor during viral infection. Its production is tightly controlled by… (More)
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Highly Cited
2009
Highly Cited
2009
A homozygous CARD9 mutation in a family with susceptibility to fungal infections.
BACKGROUND Chronic mucocutaneous candidiasis may be manifested as a primary immunodeficiency characterized by persistent or… (More)
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Highly Cited
2007
Highly Cited
2007
Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17
The C-type lectin dectin-1 binds to yeast and signals through the kinase Syk and the adaptor CARD9 to induce production of… (More)
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Highly Cited
2007
Highly Cited
2007
The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens
The caspase-recruitment domain–containing adaptor protein CARD9 regulates the innate signaling responses to fungal infection… (More)
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Highly Cited
2007
Highly Cited
2007
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors
Immunoreceptor tyrosine-based activation motifs (ITAMs) are crucial in antigen receptor signaling in acquired immunity. Although… (More)
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Highly Cited
2006
Highly Cited
2006
Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity
Fungal infections are increasing worldwide due to the marked rise in immunodeficiencies including AIDS; however, immune responses… (More)
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