Semantic Scholar uses AI to extract papers important to this topic.
The microRNA miR-451 is downregulated in gliomas, this has been suggested by several different research groups and is consistent… Expand Unc-51-like kinase 1 (Ulk1) plays a central role in autophagy induction. It forms a stable complex with Atg13 and focal adhesion… Expand To sustain tumor growth, cancer cells must be able to adapt to fluctuations in energy availability. We have identified a single… Expand The human Lkb1 kinase, encoded by the ortholog of the invertebrate Par4 polarity gene, is mutated in Peutz-Jeghers cancer… Expand The conformation of the pseudokinase STRADα, which is regulated by binding to ATP and to the scaffolding protein MO25α, is key to… Expand LKB1, a serine/threonine kinase, regulates cell polarity, metabolism, and cell growth. The activity and cellular distribution of… Expand We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the pseudokinase STRAD and the scaffolding… Expand The polarization of eukaryotic cells is controlled by the concerted activities of asymmetrically localized proteins. The PAR… Expand Mutations in the LKB1 tumour suppressor threonine kinase cause the inherited Peutz-Jeghers cancer syndrome and are also observed… Expand Mutations in the LKB1 protein kinase result in the inherited Peutz Jeghers cancer syndrome. LKB1 has been implicated in… Expand