MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and, thereby, impairing oncogenic autophagy.

@article{Xu2019MIR1265RC,
  title={MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and, thereby, impairing oncogenic autophagy.},
  author={Zhipeng Xu and Zheng Li and Weizhi Wang and Yiwen Xia and Zhongyuan He and Bowen Li and Sen Wang and Xiaoxu Huang and Guangli Sun and Jianghao Xu and Lu Wang and Qiang Zhang and Qiang Li and Jialun Lv and Linjun Wang and Lu Zhang and Diancai Zhang and Hao Xu and Zekuan Xu},
  journal={Cancer letters},
  year={2019},
  volume={449},
  pages={
          226-236
        }
}
Increasing evidence indicates that microRNAs (miRNAs) play an important role in various tumors by regulating downstream target genes and diverse signaling pathways. Herein, we confirmed miR-1265 expression in gastric cancer (GC) using the Cancer Genome Atlas (TCGA) database and assessed the level of miR-1265 expression in clinical specimens and cell lines. We found that miR-1265 expression was negatively correlated with tumor size. Further functional analysis revealed that miR-1265 suppresses… CONTINUE READING
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