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CA1P

Known as: 1,2-Benzenediol, 3-methoxy-6-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-, 1,2-bis(dihydrogen Phosphate), Combretastatin A-1 bis(phosphate), Combretastatin A1 diphosphate 
The diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and… 
National Institutes of Health

Related topics

Related topics

3 relations
Microtubule ProcessNCIt Antineoplastic Agent TerminologyOxi 4503

Papers overview

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Highly Cited
2006
Highly Cited
2006
New arylthioindoles: potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies.
Arylthioindoles (ATIs) that possess a 3-methoxyphenylthio or a 3,5-dimethoxyphenylthio moiety at position 2 of the indole ring… 
Review
2004
Review
2004
Vascular Targeting Agents as Cancer Therapeutics
Vascular targeting agents (VTAs) for the treatment of cancer are designed to cause a rapid and selective shutdown of the blood… 
Highly Cited
2004
Highly Cited
2004
Synthesis of phenanthrenes and polycyclic heteroarenes by transition-metal catalyzed cycloisomerization reactions.
Readily available biphenyl derivatives containing an alkyne unit at one of their ortho-positions are converted into substituted… 
Highly Cited
2004
Highly Cited
2004
Arylthioindoles, potent inhibitors of tubulin polymerization.
Several arylthioindoles had excellent activity as inhibitors both of tubulin polymerization and of the growth of MCF-7 human… 
Review
2003
Review
2003
Combretastatin A-4 analogues as antimitotic antitumor agents.
Tubulin protein is a major target for anticancer drug discovery. As a result, antimitotic agents constitute an important class of… 
Review
2003
Review
2003
Combretastatins: from natural products to drug discovery.
The combretastatins are a group of anti-mitotic agents isolated from the bark of the South African tree Combretum caffrum. The… 
Highly Cited
2002
Highly Cited
2002
The tumor vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells.
Combretastatin A-4-phosphate (CA-4-P) is a tubulin-binding compound currently in clinical trial as a tumor vascular-targeting… 
Review
2001
Review
2001
Angiogenesis: regulators and clinical applications.
Highly Cited
2000
Highly Cited
2000
6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
As part of our continuing search for potential anticancer candidates among 2-phenyl-4-quinolones and 2-phenyl-4-quinazolinones… 
Highly Cited
1995
Highly Cited
1995
Antineoplastic agents 322. synthesis of combretastatin A-4 prodrugs.
Combretastatin A-4 (1a), the principal cancer cell growth-inhibitory constituent of the Zulu medicinal plant Combretum caffrum… 
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