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C5a anaphylatoxin receptor

Known as: CD88, Antigen, CD88, Receptors, C5a 
A G-protein-coupled receptor that signals an increase in intracellular calcium in response to the potent ANAPHYLATOXIN peptide COMPLEMENT C5A.
National Institutes of Health

Related topics

Related topics

9 relations
C5AR1 geneIn Bloodagonistsantagonists & inhibitors

Narrower (2)

C5AR1 protein, humanC5ar2 protein, rat

Broader (1)

Complement Receptor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
C5L2: a controversial receptor of complement anaphylatoxin, C5a
C5a is the paramount proinflammatory mediator of the complement cascade, and has been previously thought to act only through a… 
Highly Cited
2011
Highly Cited
2011
The C5a Receptor Impairs IL-12–Dependent Clearance of Porphyromonas gingivalis and Is Required for Induction of Periodontal Bone Loss
The C5a anaphylatoxin receptor (C5aR; CD88) is activated as part of the complement cascade and exerts important inflammatory… 
Highly Cited
2009
Highly Cited
2009
C3a and C5a Are Chemotactic Factors for Human Mesenchymal Stem Cells, Which Cause Prolonged ERK1/2 Phosphorylation1
Mesenchymal stem cells (MSCs) have a great potential for tissue repair, especially if they can be delivered efficiently to sites… 
Highly Cited
2008
Highly Cited
2008
Functional roles for C5a receptors in sepsis
The function of the C5a receptors, C5ar (encoded by C5ar) and C5l2 (encoded by Gpr77), especially of C5l2, which was originally… 
Highly Cited
2000
Highly Cited
2000
Selective Suppression of IL-12 Production by Chemoattractants
We investigated the ability of chemoattractants to affect IL-12 production by human monocytes and dendritic cells. We found that… 
Highly Cited
1996
Highly Cited
1996
Molecular Cloning and Characterization of the Human Anaphylatoxin C3a Receptor*
In a human neutrophil cDNA library, an orphan G-protein-coupled receptor, HNFAG09, with 37% nucleotide identity to the C5a… 
Highly Cited
1995
Highly Cited
1995
Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on nonmyeloid cells of the liver and lung.
The small-complement C5 activation fragment, C5a, is a potent phlogistic molecule that, on binding to the C5a Receptor (C5aR… 
Highly Cited
1991
Highly Cited
1991
Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells.
A cDNA clone encoding the human C5a anaphylatoxin receptor has been isolated by expression cloning from a CDM8 expression library… 
Highly Cited
1985
Highly Cited
1985
Mechanism of action of the group A streptococcal C5a inactivator.
Virulent group A streptococci have been found to express a cell-surface factor that has the capability of inactivating complement… 
Highly Cited
1982
Highly Cited
1982
Induction of interleukin 1 secretion and enhancement of humoral immunity by binding of human C5a to macrophage surface C5a receptors
The mechanism by which human C5a anaphylatoxin augments the primary humoral response of murine splenocytes to antigen has been… 
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