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C5a anaphylatoxin receptor

Known as: CD88, Antigen, CD88, Receptors, C5a 
A G-protein-coupled receptor that signals an increase in intracellular calcium in response to the potent ANAPHYLATOXIN peptide COMPLEMENT C5A.
National Institutes of Health

Papers overview

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Review
2013
Review
2013
C5a is the paramount proinflammatory mediator of the complement cascade, and has been previously thought to act only through a… Expand
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Highly Cited
2009
Highly Cited
2009
Anti-neutrophil cytoplasmic autoantibody (ANCA)-induced necrotizing crescentic glomerulonephritis (NCGN) requires complement… Expand
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Highly Cited
2008
Highly Cited
2008
The function of the C5a receptors, C5ar (encoded by C5ar) and C5l2 (encoded by Gpr77), especially of C5l2, which was originally… Expand
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Highly Cited
2007
Highly Cited
2007
Microarray expression profiles reveal substantial changes in gene expression in the ipsilateral dorsal horn of the spinal cord in… Expand
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Highly Cited
2003
Highly Cited
2003
Antiphospholipid syndrome (APS) is defined by recurrent pregnancy loss and thrombosis in the presence of antiphospholipid (aPL… Expand
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Highly Cited
2003
Highly Cited
2003
C5a anaphylatoxin, a potent inflammatory mediator, is known to act through a specific G protein coupled receptor. However, some… Expand
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Highly Cited
2002
Highly Cited
2002
  • S. Cain, P. Monk
  • The Journal of Biological Chemistry
  • 2002
  • Corpus ID: 12896809
The substantial variations in the responses of cells to the anaphylatoxin C5a and its desarginated form, C5adR74, suggest that… Expand
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Highly Cited
1995
Highly Cited
1995
The small-complement C5 activation fragment, C5a, is a potent phlogistic molecule that, on binding to the C5a Receptor (C5aR… Expand
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Highly Cited
1991
Highly Cited
1991
A cDNA clone encoding the human C5a anaphylatoxin receptor has been isolated by expression cloning from a CDM8 expression library… Expand
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Highly Cited
1978
Highly Cited
1978
Human C5a was maximally active over a narrow concentration range of 2 to 6 × 10-7 M as estimated in rabbits by utilizing a skin… Expand
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