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C5a anaphylatoxin receptor

Known as: CD88, Antigen, CD88, Receptors, C5a 
A G-protein-coupled receptor that signals an increase in intracellular calcium in response to the potent ANAPHYLATOXIN peptide COMPLEMENT C5A.
National Institutes of Health

Papers overview

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Review
2011
Review
2011
Activation of the complement system is a major pathogenic event that drives various inflammatory responses in numerous diseases… Expand
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Highly Cited
2009
Highly Cited
2009
Anti-neutrophil cytoplasmic autoantibody (ANCA)-induced necrotizing crescentic glomerulonephritis (NCGN) requires complement… Expand
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Highly Cited
2008
Highly Cited
2008
The function of the C5a receptors, C5ar (encoded by C5ar) and C5l2 (encoded by Gpr77), especially of C5l2, which was originally… Expand
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Review
2007
Review
2007
Complement fragment (C)5a is a 74 residue pro‐inflammatory polypeptide produced during activation of the complement cascade of… Expand
Highly Cited
2007
Highly Cited
2007
Microarray expression profiles reveal substantial changes in gene expression in the ipsilateral dorsal horn of the spinal cord in… Expand
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Highly Cited
2003
Highly Cited
2003
Antiphospholipid syndrome (APS) is defined by recurrent pregnancy loss and thrombosis in the presence of antiphospholipid (aPL… Expand
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Highly Cited
2003
Highly Cited
2003
C5a anaphylatoxin, a potent inflammatory mediator, is known to act through a specific G protein coupled receptor. However, some… Expand
Highly Cited
2001
Highly Cited
2001
The presence of the complement-derived anaphylatoxin peptides, C3a and C5a, in the lung can induce respiratory distress… Expand
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Highly Cited
1978
Highly Cited
1978
Human C5a was maximally active over a narrow concentration range of 2 to 6 × 10-7 M as estimated in rabbits by utilizing a skin… Expand
Highly Cited
1968
Highly Cited
1968
Anaphylatoxin activity was derived from both human C'5 and C'3 molecules. This was achieved in the case of C'5 by interaction… Expand
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