C5a anaphylatoxin receptor
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Activation of the complement system is a major pathogenic event that drives various inflammatory responses in numerous diseases… Expand Anti-neutrophil cytoplasmic autoantibody (ANCA)-induced necrotizing crescentic glomerulonephritis (NCGN) requires complement… Expand The function of the C5a receptors, C5ar (encoded by C5ar) and C5l2 (encoded by Gpr77), especially of C5l2, which was originally… Expand Complement fragment (C)5a is a 74 residue pro‐inflammatory polypeptide produced during activation of the complement cascade of… Expand Microarray expression profiles reveal substantial changes in gene expression in the ipsilateral dorsal horn of the spinal cord in… Expand Antiphospholipid syndrome (APS) is defined by recurrent pregnancy loss and thrombosis in the presence of antiphospholipid (aPL… Expand C5a anaphylatoxin, a potent inflammatory mediator, is known to act through a specific G protein coupled receptor. However, some… Expand The presence of the complement-derived anaphylatoxin peptides, C3a and C5a, in the lung can induce respiratory distress… Expand Human C5a was maximally active over a narrow concentration range of 2 to 6 × 10-7 M as estimated in rabbits by utilizing a skin… Expand Anaphylatoxin activity was derived from both human C'5 and C'3 molecules. This was achieved in the case of C'5 by interaction… Expand