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C4 Deficiency

Lack of production of functional C4 protein, due to a genetic defect requiring homozygous loss of both the C4A and C4B genetic paralogs… 
National Institutes of Health

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Complement deficiency

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Kidney transplantation in patients suffering from hereditary complete complement C4 deficiency
Hereditary complete C4 deficiency (C4def) is a very rare condition that predisposes to immune complex disease and end‐stage renal… 
2001
2001
Complement C4 deficiency and HLA homozygosity in patients with frequent intraoral herpes simplex virus type 1 infections.
Three consecutive patients with no apparent immunodeficiency who had frequent intraoral herpes simplex type 1 recurrences, a rare… 
1996
1996
Antibody to C1-inhibitor in a patient receiving C1-inhibitor infusions for treatment of hereditary angioneurotic edema with systemic lupus erythematosus reacts with a normal allotype of residue 458…
1995
1995
Familial anticardiolipin antibodies and C4 deficiency genotypes that coexist with MHC DQB1 risk factors.
OBJECTIVE To investigate the familial basis of antiphospholipid antibodies by studying putative risk factors at the C4 and MHC… 
1993
1993
Serum complement (C3, BF, C4) types in Swedish Saamis.
Serum complement (C3, BF, C4) types were examined in Swedish Saamis (Lapps). In agreement with previous studies, a very low… 
1989
1989
Molecular basis of complete C4 deficiency. A study of three patients.
1987
1987
Metabolism of C4 and linkage analysis in a kindred with hereditary incomplete C4 deficiency.
We studied a kindred in which C4 deficiency had been discovered. Unlike families with total absence of C4, in this kindred C4… 
Highly Cited
1983
Highly Cited
1983
Use of a cDNA clone for the fourth component of human complement (C4) for analysis of a genetic deficiency of C4 in guinea pig.
A cDNA clone for the fourth complement component (C4), pC4AL1, has been isolated from a human adult liver cDNA library by using a… 
1981
1981
Familial systemic lupus erythematosus and C4 deficiency.
A heterozygous state for C4 deficiency was found in 14 members of a family with familial SLE. The HLA analysis in this family… 
1976
1976
Linkage of C4 Deficiency to the Major Histocompatibility Locus in the Guinea Pig
C4 deficient (C4D) guinea pigs have a deficiency in C4 synthesis that appears to be due to a structural gene defect. Previous… 
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