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Bz-423

Known as: 1,4-benzodiazepine 
National Institutes of Health

Related topics

Related topics

2 relations
1,4-benzodiazepine-2,5-dione

Broader (1)

Benzodiazepines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Novel peptidomimetics containing a vinyl ester moiety as highly potent and selective falcipain-2 inhibitors.
This paper describes the synthesis and biological evaluation of a new class of peptidomimetic falcipain-2 inhibitors based on a 1… 
2004
2004
Design and synthesis of a potent and selective peptidomimetic inhibitor of caspase-3.
In this paper we report the synthesis and characterization of a novel potent and selective inhibitor of caspase-3, a member of… 
2003
2003
The proapoptotic benzodiazepine Bz-423 affects the growth and survival of malignant B cells.
Bz-423 is a novel proapoptotic 1,4-benzodiazepine that induces cell death via a superoxide signal. Previous work has shown that… 
Highly Cited
1999
Highly Cited
1999
Determination of 1,4-benzodiazepines and their metabolites by capillary electrophoresis and high-performance liquid chromatography using ultraviolet and electrospray ionisation mass spectrometry.
Highly Cited
1997
Highly Cited
1997
Germanium and Silicon Linking Strategies for Traceless Solid-Phase Synthesis.
Here we describe the development and application of germanium and silicon linkage strategies for the solid-phase synthesis of… 
1985
1985
Clonazepam-induced hyperphagia in nondeprived rats: Tests of pharmacological specificity with R05-4864, Ro5-3663, Ro15-1788 and CGS 9896
Highly Cited
1984
Highly Cited
1984
RO5-4864 inhibits the binding of [35S]t-butylbicyclophosphorothionate to rat brain membranes.
1983
1983
Kinetics and equilibrium of the reversible alprazolam ring-opening reaction.
Alprazolam underwent a facile 1,4-benzodiazepine ring-opening reaction in an acidic aqueous solution to form a benzophenone… 
1979
1979
1,4-Benzodiazepines and gamma-aminobutyric acid: pharmacological and biochemical correlates.
The high affinity receptors or GABA present in brain interact with an endogenous thermostable inhibitor (GABA modulin) which… 
Review
1971
Review
1971
1,4-benzodiazepines. Chemistry and some aspects of the structure-activity relationship.
Numerous clinically used compounds having favorable tranquilizing and toxic properties possess the 1,4-benzodiazepine skeleton… 
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