Bongkrekic Acid

Known as: 2,4,8,10,14,18,20-Docosaheptaenedioic acid, 20-(carboxymethyl)-6-methoxy-2,5,17-trimethyl-, (R-(R*,S*-(E,Z,Z,E,E,Z,E)))-, Bongkrekic Acid [Chemical/Ingredient], Flavotoxin A 
An antibiotic produced by Pseudomonas cocovenenans. It is an inhibitor of MITOCHONDRIAL ADP, ATP TRANSLOCASES. Specifically, it blocks adenine… (More)
National Institutes of Health

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Topic mentions per year

1970-2018
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Papers overview

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2007
2007
The aim of this work was to characterize the effect of bongkrekic acid (BKA), atractyloside (ATR) and carboxyatractyloside (CAT… (More)
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Highly Cited
2005
Highly Cited
2005
Huntington's disease (HD) is caused by polyglutamine expansion (exp) in huntingtin. Here, we used a yeast artificial chromosome… (More)
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2001
Highly Cited
2001
The accumulation of hydrophobic bile acids plays a role in the induction of apoptosis and necrosis of hepatocytes during… (More)
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Highly Cited
2000
Highly Cited
2000
We sought to understand the relationship between reactive oxygen species (ROS) and the mitochondrial permeability transition (MPT… (More)
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Highly Cited
2000
Highly Cited
2000
Many apoptotic signaling pathways are directed to mitochondria, where they initiate the release of apoptogenic proteins and open… (More)
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Highly Cited
1998
Highly Cited
1998
Cytochrome c release and the mitochondrial permeability transition (PT), including loss of the transmembrane potential (Deltapsi… (More)
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Highly Cited
1998
Highly Cited
1998
Different classes of anticancer drugs may trigger apoptosis by acting on different subcellular targets and by activating distinct… (More)
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Highly Cited
1996
Highly Cited
1996
In a number of experimental systems, the early stage of the apoptotic process, i.e., the stage that precedes nuclear… (More)
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Highly Cited
1990
Highly Cited
1990
1. Isolated rat liver and heart mitochondria incubated in 150 mM-KSCN or sucrose medium in the presence of respiratory-chain… (More)
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1970
1970
The antibiotic bongkrekic acid is shown to inhibit the phosphorylation of added ADP coupled with either the reactions of the… (More)
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