Bisindolylmaleimide IX Methanesulfonate
National Institutes of Health
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The overexpression and hypersecretion of mucus is a hallmark of several chronic pulmonary inflammatory diseases, including…
We previously reported that some ATP competitive protein kinase C (PKC) inhibitors are either competitive or uncompetitive…
The bisindolylmaleimides are selective protein kinase inhibitors that can adopt two limiting diastereomeric (syn and anti…
The effect of macrocycle size and substitution on the configurational stability of some bisindolylmaleimide cyclophanes was…
There is growing evidence that E‐type voltage dependent Ca2+ channels (Cav2.3) are involved in triggering and controlling pivotal…
The aims of this study were to investigate the effects of a selective ETA (BQ-123), a selective ETB (BQ-788), and a specific…
We previously reported that proinflammatory mediator bradykinin (BK) induces cyclooxygenase (COX)-2 expression in human airway…
To elucidate the response to oxidative stress in eukaryotic cells, the effect of an oxidized nucleotide, 8-oxo-2'-deoxyguanosine…
Protein kinase C delta (PKC delta) is activated through tyrosine phosphorylation and is involved in apoptosis induction in the H…
Endothelin-1 (ET-1) is a potent vasoconstrictor peptide that also stimulates production of prostacyclin (PGI2) from arachidonic…