Ro 31-8220

Known as: Ro31-8220, Ro-31-8220, Ro 318220 
A methanesulfonate salt form, a staurosporine analog that inhibits protein kinase C and induces apoptosis. (NCI)

Topic mentions per year

Topic mentions per year

1990-2016
020406019902016

Papers overview

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Highly Cited
2001
Highly Cited
2001
The activity of the endothelial nitric oxide synthase (eNOS) can be regulated independently of an increase in Ca(2+) by the… (More)
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Highly Cited
2000
Highly Cited
2000
The specificities of 28 commercially available compounds reported to be relatively selective inhibitors of particular serine… (More)
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2000
2000
A series of bisindolylmaleimide (Bis) compounds were designed as analogs of the natural compound staurosporine (STS), which is a… (More)
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2000
2000
We find that several protein kinase C (PKC) inhibitors, previously considered to be specific, directly inhibit voltage-dependent… (More)
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1999
1999
Here we report that the widely used protein kinase C inhibitors, bisindolylmaleimide I and IX, are potent inhibitors of glycogen… (More)
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Highly Cited
1998
Highly Cited
1998
We have identified a novel mitogen- and stress-activated protein kinase (MSK1) that contains two protein kinase domains in a… (More)
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Highly Cited
1996
Highly Cited
1996
The Drosophila gene product Wingless (Wg) is a secreted glycoprotein and a member of the Wnt gene family. Genetic analysis of… (More)
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Highly Cited
1996
Highly Cited
1996
The role of protein kinase C (PKC) in inflammation, mitogenesis, and differentiation has been deduced in part through the use of… (More)
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1996
1996
The involvement of protein kinase C (PKC) isoforms in glucose-induced insulin secretion was investigated by comparing the effects… (More)
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1993
1993
The PKC-inhibitor Ro 31-8220 inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate… (More)
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