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Beta-1,4-Galactosyltransferase 1

Known as: Glycoprotein-4-Beta-Galactosyltransferase 2, UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,4-Galactosyltransferase 1, EC 2.4.1.- 
Beta-1,4-galactosyltransferase 1 (398 aa, ~44 kDa) is encoded by the human B4GALT1 gene. This protein plays a role in the biosynthesis of lactose.
National Institutes of Health

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11 relations
B4GALT1 geneB4GALT1 wt AlleleCarbohydrate MetabolismEnzyme Gene
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Polyclonal Immunoglobulin G N-Glycosylation in the Pathogenesis of Plasma Cell Disorders.
The pathological progression from benign monoclonal gammopathy of undetermined significance (MGUS) to smoldering myeloma (SMM… Expand
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2016
2016
MiR-124-3p/B4GALT1 axis plays an important role in SOCS3-regulated growth and chemo-sensitivity of CML
BackgroundAbnormal expression of SOCS3 has been implicated in myeloproliferative neoplasms, but the role of SOCS3 in the… Expand
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2015
2015
Multifaceted roles of 5'-regulatory region of the cancer associated gene B4GALT1 and its comparison with the gene family.
β1,4-Galactosylransferases are a family of enzymes encoded by seven B4GALT genes and are involved in the development of… Expand
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2014
2014
Genome-Wide and Gene-Specific Epigenomic Platforms for Hepatocellular Carcinoma Biomarker Development Trials
The majority of the epigenomic reports in hepatocellular carcinoma have focused on identifying novel differentially methylated… Expand
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2013
2013
B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1
β-1, 4-Galactosyltransferase gene (B4GALT) family consists of seven members, which encode corresponding enzymes known as type II… Expand
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2012
2012
B4GALT1 gene knockdown inhibits the hedgehog pathway and reverses multidrug resistance in the human leukemia K562/adriamycin-resistant cell line.
B4GALT1 gene encodes type II membrane-bound glycoprotein, named β-1, 4-galactosyltransferase 1 (β1, 4-Gal-T1), which can transfer… Expand
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2012
2012
Estrogen induced β-1,4-galactosyltransferase 1 expression regulates proliferation of human breast cancer MCF-7 cells.
Beta 1,4-galactosyltransferase 1 (B4GALT1) synthesizes galactose β-1,4-N-acetylglucosamine (Galβ1-4GlcNAc) groups on N-linked… Expand
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Highly Cited
2011
Highly Cited
2011
Plasma N-glycan profiling by mass spectrometry for congenital disorders of glycosylation type II.
BACKGROUND Determination of the genetic defect in patients with a congenital disorder of glycosylation (CDG) is challenging… Expand
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Highly Cited
2011
Highly Cited
2011
Conserved oligomeric Golgi complex specifically regulates the maintenance of Golgi glycosylation machinery.
Cell surface lectin staining, examination of Golgi glycosyltransferases stability and localization, and matrix-assisted laser… Expand
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2011
2011
Differential effects of lobe A and lobe B of the Conserved Oligomeric Golgi complex on the stability of {beta}1,4-galactosyltransferase 1 and {alpha}2,6-sialyltransferase 1.
Initially described by Jaeken et al. in 1980, congenital disorders of glycosylation (CDG) is a rapidly expanding group of human… Expand
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