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Specific glycosphingolipids mediate epithelial-to-mesenchymal transition of human and mouse epithelial cell lines
Observations indicate that specific GSLs play key roles in defining phenotypes associated with EMT and its reverse process (i.e., mesenchymal-to-epithelial transition), as well as specific GSL changes and EMT processes induced by EtDO-P4 or TGF-β.
Role of Glycans in Cancer Cells Undergoing Epithelial–Mesenchymal Transition
Better understanding of the mechanisms underlying aberrant glycan patterns in EMT and cancer will facilitate the development of such glycans as cancer biomarkers or as targets in design and synthesis of anti-tumor drugs.
Biological Functions and Analytical Strategies of Sialic Acids in Tumor
The present state of knowledge on the metabolic pathway of human sIALic acids, the function of hypersialylation in tumors, as well as the recent labeling and analytical techniques for sialic acids are outlined.
Genetic disruption of multiple α1,2-mannosidases generates mammalian cells producing recombinant proteins with high-mannose–type N-glycans
The results indicate that the triple KO HEK293 cells are suitable for producing recombinant proteins, including lysosomal enzymes with high-mannose–type N-glycans, including α-galactosidase-A and lysOSomal acid lipase, which were sensitive to endoglycosidase H treatment.
Conditioned Medium from Malignant Breast Cancer Cells Induces an EMT-Like Phenotype and an Altered N-Glycan Profile in Normal Epithelial MCF10A Cells
CM derived from breast cancer cells induced an EMT-like process in normal epithelial cells and altered their N-glycan profile, showing that communication between cancer cells and normal cells may facilitate cancer progression.
A pilot study of salivary N-glycome in HBV-induced chronic hepatitis, cirrhosis, and hepatocellular carcinoma
The data provide pivotal information to distinguish between HBV-associated hepatitis, cirrhosis and HCC, and facilitate the discovery of biomarkers for HCC during its early stages based on precise alterations of N-linked glycans in saliva.
Curcumin Suppresses Proliferation and Migration of MDA-MB-231 Breast Cancer Cells through Autophagy-Dependent Akt Degradation
Results indicate that curcumin-stimulated AMPK activity induces activation of the autophagy-lysosomal protein degradation pathway leading to Akt degradation and the subsequent suppression of proliferation and migration in breast cancer cell.
Quantitative glycome analysis of N-glycan patterns in bladder cancer vs normal bladder cells using an integrated strategy.
Findings indicate that sialyl Lewis X (sLe(x), terminal GalNAc and Gal, and high mannose-type N-glycans were more highly expressed in bladder cancer cells and tissues than in normal cells.
Functional role of gangliotetraosylceramide in epithelial-to-mesenchymal transition process induced by hypoxia and by TGF-{beta}.
The epithelial-to-mesenchymal transition (EMT) is a basic cellular process that plays a key role in normal embryonic development and in cancer progression/metastasis. Our previous study indicated