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BZA 5B

Known as: BZA-5B 
National Institutes of Health

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2 relations

Broader (2)

BenzodiazepinesOligopeptides

Papers overview

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Highly Cited
2002
Highly Cited
2002
A Prenylation Inhibitor Prevents Production of Infectious Hepatitis Delta Virus Particles
ABSTRACT Hepatitis delta virus (HDV) causes both acute and chronic liver disease throughout the world. Effective medical therapy… 
Highly Cited
1997
Highly Cited
1997
Pharmacological control of the mevalonate pathway: effect on arterial smooth muscle cell proliferation.
The mevalonate (MVA) pathway is involved in cell proliferation. We investigated drugs acting at different enzymatic steps on rat… 
Highly Cited
1997
Highly Cited
1997
Induction of Cytosolic Phospholipase A2 by Oncogenic Ras in Human Non-small Cell Lung Cancer*
Mutations in Ras family members that confer oncogenic potential are frequently observed in specific human cancers. We report that… 
1997
1997
The Ras farnesylation inhibitor BZA-5B increases the resistance to cisplatin in a human melanoma cell line.
Ras proteins have been implicated in transducing cellular responses to DNA damaging agents. We used BZA-5B, an inhibitor of Ras… 
Highly Cited
1996
Highly Cited
1996
Prenylation of an interferon‐γ‐induced GTP‐binding protein: the human guanylate binding protein, huGBP1
Interferons (IFN) and lipopolysaccharide (LPS) cause multiple changes in isoprenoid‐modified proteins in murine macrophages, the… 
Highly Cited
1996
Highly Cited
1996
Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells.
Benzodiazepine (BZA)-5B, a CAAX farnesyl-transferase inhibitor, was previously shown to block the farnesylation of H-Ras and to… 
Highly Cited
1996
Highly Cited
1996
Regulation of Cytokine-inducible Nitric Oxide Synthase in Cardiac Myocytes and Microvascular Endothelial Cells
Adult rat ventricular myocytes and cardiac microvascular endothelial cells (CMEC) both express an inducible nitric oxide synthase… 
Highly Cited
1995
Highly Cited
1995
The farnesyl protein transferase inhibitor BZA-5B blocks farnesylation of nuclear lamins and p21ras but does not affect their function or localization.
BZA-5B is a peptidomimetic inhibitor of protein farnesylation in mammalian cells. We have examined the specificity of this… 
Highly Cited
1995
Highly Cited
1995
Polylysine and CVIM Sequences of K-RasB Dictate Specificity of Prenylation and Confer Resistance to Benzodiazepine Peptidomimetic in Vitro(*)
BZA-5B, a benzodiazepine peptidomimetic, inhibits CAAX farnesyltransferase (FTase) and blocks attachment of farnesyl groups to… 
Highly Cited
1994
Highly Cited
1994
Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells.
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