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BZA 5B

Known as: BZA-5B 
National Institutes of Health

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2 relations

Broader (2)

BenzodiazepinesOligopeptides

Papers overview

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2005
2005
Resistance of K-RasBVl 2 proteins to farnesyltransferase inhibitors in Ratl cells ( protein prenylation / geranylgeranyl transferase I / transformed cells / benzodiazepine-5 B / L-739 , 749 )
Benzodiazepine (BZA)-5B, a CAAX farnesyltransferase inhibitor, was previously shown to block the farnesylation of H-Ras and to… 
1998
1998
MEK and ERK activation in ras-disabled RBL-2H3 mast cells and novel roles for geranylgeranylated and farnesylated proteins in Fc epsilonRI-mediated signaling.
Cross-linking the high affinity IgE receptor Fc epsilonRI of basophils and mast cells activates receptor-associated protein… 
1998
1998
Down-regulation of tropomyosin-2 expression in c-Jun-transformed rat fibroblasts involves induction of a MEK1-dependent autocrine loop.
Overexpression of the c-Jun transcription factor in rodent fibroblasts may result in cell transformation or in apoptosis. The… 
1998
1998
The prenylation inhibitor BZA-5B prevents virus particle assembly
1997
1997
The Ras farnesylation inhibitor BZA-5B increases the resistance to cisplatin in a human melanoma cell line.
Ras proteins have been implicated in transducing cellular responses to DNA damaging agents. We used BZA-5B, an inhibitor of Ras… 
1997
1997
Expression of Wnt5a is downregulated by extracellular matrix and mutated c-Ha-ras in the human mammary epithelial cell line MCF-10A.
Wnt genes are involved in tumour growth and regulate cell adhesion. Some (Wnt5a and Wnt7b) are more highly expressed in human… 
1997
1997
[Pharmacological control of biosynthesis pathway of mevalonate: effect on the proliferation of arterial smooth muscle cells].
The role of mevalonic acid (MVA) and its products (isoprenoids) in cell proliferation prompted us to investigate the effect of… 
1995
1995
Induction of a prenylated 65‐kd protein in macrophages by interferon or lipopolysaccharide
Treatment of murine bone marrow‐derived macrophages with interferon‐γ (IFN‐γ) and/or lipopolysaccharide (LPS) resulted in changes… 
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