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BZA 5B
Known as:
BZA-5B
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Benzodiazepines
Oligopeptides
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
A Prenylation Inhibitor Prevents Production of Infectious Hepatitis Delta Virus Particles
B. Bordier
,
P. Marion
,
+4 authors
J. Glenn
Journal of Virology
2002
Corpus ID: 6680683
ABSTRACT Hepatitis delta virus (HDV) causes both acute and chronic liver disease throughout the world. Effective medical therapy…
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Highly Cited
1997
Highly Cited
1997
Pharmacological control of the mevalonate pathway: effect on arterial smooth muscle cell proliferation.
M. Raiteri
,
L. Arnaboldi
,
+9 authors
A. Corsini
The Journal of pharmacology and experimental…
1997
Corpus ID: 10929708
The mevalonate (MVA) pathway is involved in cell proliferation. We investigated drugs acting at different enzymatic steps on rat…
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Highly Cited
1997
Highly Cited
1997
Induction of Cytosolic Phospholipase A2 by Oncogenic Ras in Human Non-small Cell Lung Cancer*
L. Heasley
,
S. Thaler
,
M. Nicks
,
B. Price
,
K. Skorecki
,
R. Nemenoff
The Journal of Biological Chemistry
1997
Corpus ID: 35148288
Mutations in Ras family members that confer oncogenic potential are frequently observed in specific human cancers. We report that…
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1997
1997
The Ras farnesylation inhibitor BZA-5B increases the resistance to cisplatin in a human melanoma cell line.
T. Fokstuen
,
Y. Rabo
,
+5 authors
S. Linder
Anticancer research
1997
Corpus ID: 9564063
Ras proteins have been implicated in transducing cellular responses to DNA damaging agents. We used BZA-5B, an inhibitor of Ras…
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Highly Cited
1996
Highly Cited
1996
Prenylation of an interferon‐γ‐induced GTP‐binding protein: the human guanylate binding protein, huGBP1
D. Nantais
,
M. Schwemmle
,
J. T. Stickney
,
D. Vestal
,
J. Buss
Journal of leukocyte biology
1996
Corpus ID: 33727864
Interferons (IFN) and lipopolysaccharide (LPS) cause multiple changes in isoprenoid‐modified proteins in murine macrophages, the…
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Highly Cited
1996
Highly Cited
1996
Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells.
G. James
,
J. Goldstein
,
M. Brown
Proceedings of the National Academy of Sciences…
1996
Corpus ID: 24606801
Benzodiazepine (BZA)-5B, a CAAX farnesyl-transferase inhibitor, was previously shown to block the farnesylation of H-Ras and to…
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Highly Cited
1996
Highly Cited
1996
Regulation of Cytokine-inducible Nitric Oxide Synthase in Cardiac Myocytes and Microvascular Endothelial Cells
K. Singh
,
J. Balligand
,
T. Fischer
,
Thomas W. Smith
,
R. Kelly
The Journal of Biological Chemistry
1996
Corpus ID: 40341828
Adult rat ventricular myocytes and cardiac microvascular endothelial cells (CMEC) both express an inducible nitric oxide synthase…
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Highly Cited
1995
Highly Cited
1995
The farnesyl protein transferase inhibitor BZA-5B blocks farnesylation of nuclear lamins and p21ras but does not affect their function or localization.
M. Dalton
,
K. Fantle
,
+4 authors
M. Sinensky
Cancer research
1995
Corpus ID: 2988654
BZA-5B is a peptidomimetic inhibitor of protein farnesylation in mammalian cells. We have examined the specificity of this…
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Highly Cited
1995
Highly Cited
1995
Polylysine and CVIM Sequences of K-RasB Dictate Specificity of Prenylation and Confer Resistance to Benzodiazepine Peptidomimetic in Vitro(*)
G. James
,
J. Goldstein
,
Michael S. Brown
The Journal of Biological Chemistry
1995
Corpus ID: 31131063
BZA-5B, a benzodiazepine peptidomimetic, inhibits CAAX farnesyltransferase (FTase) and blocks attachment of farnesyl groups to…
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Highly Cited
1994
Highly Cited
1994
Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells.
G. James
,
M. Brown
,
M. Cobb
,
J. Goldstein
The Journal of biological chemistry
1994
Corpus ID: 36041006
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