• Publications
  • Influence
Novel patterns of genome rearrangement and their association with survival in breast cancer.
TLDR
Analysis of a selected subset of clinical material suggests that a simple genomic calculation, based on the number and proximity of genomic alterations, correlates with life-table estimates of the probability of overall survival in patients with primary breast cancer. Expand
Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix.
TLDR
It is concluded that the gain of chromosome 3q that occurs in HPV16-infected, aneuploid cells represents a pivotal genetic aberration at the transition from severe dysplasia/CIS to invasive cervical carcinoma. Expand
Intrinsic molecular signature of breast cancer in a population-based cohort of 412 patients
TLDR
The intrinsic gene set, originally selected to reveal stable tumor characteristics, was shown to have a strong correlation with progression-related properties such as grade, p53 mutation and genomic instability. Expand
Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors
TLDR
It is observed that crude aneuploidy and increased proliferative activity are early events in colorectal carcinogenesis, followed by TP53 overexpression and the acquisition of recurrent chromosomal gains and losses during the progression from high‐grade adenomas to invasive carcinomas. Expand
Advanced‐stage cervical carcinomas are defined by a recurrent pattern of chromosomal aberrations revealing high genetic instability and a consistent gain of chromosome arm 3q
TLDR
This study confirms the importance of a gain of chromosome arm 3q in cervical carcinogenesis and identifies additional, recurrent chromosomal aberrations that are required for progression from stage I tumors to advanced‐stage carcinomas. Expand
Genetic aberrations in adrenocortical tumors detected using comparative genomic hybridization correlate with tumor size and malignancy.
TLDR
There was a strong relationship between the number of genetic aberrations detected using CGH and both tumor size and malignancy, and the CGH results implicate several chromosomal regions that may contain genes with an important role in the development of adrenocortical cancers. Expand
Prognostic factors in parathyroid cancer: A review of 95 cases
TLDR
It is concluded that histopathology alone is unable to confirm a cancer diagnosis in the absence of infiltration and/or metastases, and patients should be followed closely because recurrence may occur late. Expand
Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations
TLDR
The results indicate that the aneuploid tumor cell lines have an increased sensitivity to these reagents and a delay in aster formation and microtubule regrowth, but the notion that the integrity of the centrosome plays a central role in the development of aneuPLoidy is supported. Expand
Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancer.
TLDR
It is concluded that the detection of 3q gain and amplification of TERC in routinely collected Pap smears can assist in identifying low-grade lesions with a high progression risk and in decreasing false-negative cytological screenings. Expand
Comparative genomic hybridization analysis of tonsillar cancer reveals a different pattern of genomic imbalances in human papillomavirus‐positive and ‐negative tumors
TLDR
As expected, patients with an HPV‐positive tumor had a statistically significantly better disease‐specific survival than patients with a HPV‐negative tumor, and the most common changes, e.g., gain on 3q or 8q, loss on 11q or 13 and loss on chromosome 7q in HPV‐ negative tumors, did not have any influence on prognosis. Expand
...
1
2
3
4
5
...