Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

BX795

 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

PyrimidinesThiophenes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye
Herpes simplex virus type 1 (HSV-1) causes recurrent mucocutaneous lesions in the eye that may advance to corneal blindness… Expand
Is this relevant?
2018
2018
Activation of stimulator of interferon genes (STING) induces ADAM17-mediated shedding of the immune semaphorin SEMA4D
Stimulator of interferon genes (STING) is an endoplasmic reticulum–resident membrane protein that mediates cytosolic pathogen DNA… Expand
Is this relevant?
2016
2016
Innate immune responses in human hepatocyte-derived cell lines alter genotype 1 hepatitis E virus replication efficiencies
Hepatitis E virus (HEV) is a significant health problem in developing countries causing sporadic and epidemic forms of acute… Expand
Is this relevant?
2015
2015
BX795, a TBK1 inhibitor, exhibits antitumor activity in human oral squamous cell carcinoma through apoptosis induction and mitotic phase arrest.
TANK-binding kinase 1 (TBK1), a member of IκB Kinase (IKK)-related kinases, plays a role in regulating innate immunity… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2014
2014
TLR3 and MDA5 signalling, although not expression, is impaired in asthmatic epithelial cells in response to rhinovirus infection.
BACKGROUND Rhinoviruses (RV) are the most common acute triggers of asthma, and airway epithelial cells are the primary site of… Expand
Is this relevant?
2014
2014
PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses.
3-phosphoinositide-dependent protein kinase 1 (PDK1), a member of the protein A,G and C (AGC) family of proteins, is a Ser/Thr… Expand
Is this relevant?
2013
2013
Interferon regulatory factor 3 activation mediates viral stimulus-induced bronchial production of thymic stromal lymphopoietin.
  • Lena Uller
  • The Journal of allergy and clinical immunology
  • 2013
    • Corpus ID: 26724246
To the Editor: I read with interest the report by Lee et al showing respiratory syncytial virus (RSV)-induced production of… Expand
Is this relevant?
2012
2012
Inhibition of intracellular antiviral defense mechanisms augments lentiviral transduction of human natural killer cells: implications for gene therapy.
Adoptive immunotherapy with genetically modified natural killer (NK) cells is a promising approach for cancer treatment. Yet… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2012
2012
Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.
The design, synthesis and structure-activity relationships of a novel series of 2,4-diamino-5-cyclopropyl pyrimidines is… Expand
  • figure 1
  • table 1
  • figure 2
  • table 2
  • figure 3
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and…
TANK-binding kinase 1 (TBK1) and IkappaB kinase epsilon (IKKepsilon) regulate the production of Type 1 interferons during… Expand
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE