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BX795

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2009-2018
012320092018

Related topics

Related topics

2 relations

Broader (2)

PyrimidinesThiophenes

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
BX795
Pyrimidines
Thiophenes

Papers overview

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2018
2018
An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye.
Herpes simplex virus type 1 (HSV-1) causes recurrent mucocutaneous lesions in the eye that may advance to corneal blindness… (More)
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2017
2017
Brief Report: Blockade of TANK-Binding Kinase 1/IKKÉ› Inhibits Mutant Stimulator of Interferon Genes (STING)-Mediated Inflammatory Responses in Human Peripheral Blood Mononuclear Cells.
OBJECTIVE Gain-of-function mutations in TMEM173, encoding the stimulator of interferon (IFN) genes (STING) protein, underlie a… (More)
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2016
2016
Innate immune responses in human hepatocyte-derived cell lines alter genotype 1 hepatitis E virus replication efficiencies
Hepatitis E virus (HEV) is a significant health problem in developing countries causing sporadic and epidemic forms of acute… (More)
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Review
2016
Review
2016
Significance of optineurin mutations in glaucoma and other diseases.
Glaucoma is one of the leading causes of bilateral blindness, affecting nearly 57 million people worldwide. Glaucoma is… (More)
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2016
2016
Inhibition of Phospho-S6 Kinase, a Protein Involved in the Compensatory Adaptive Response, Increases the Efficacy of Paclitaxel in Reducing the Viability of Matrix-Attached Ovarian Cancer Cells
OBJECTIVE To identify the proteins involved the compensatory adaptive response to paclitaxel in ovarian cancer cells and to… (More)
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2015
2015
BX795, a TBK1 inhibitor, exhibits antitumor activity in human oral squamous cell carcinoma through apoptosis induction and mitotic phase arrest.
TANK-binding kinase 1 (TBK1), a member of IκB Kinase (IKK)-related kinases, plays a role in regulating innate immunity… (More)
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Review
2015
Review
2015
TBK1 inhibitors: a review of patent literature (2011 - 2014).
INTRODUCTION TANK-binding kinase 1 (TBK1) is a noncanonical IκB kinase family member that regulates the innate immune response… (More)
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2014
2014
TLR3 and MDA5 signalling, although not expression, is impaired in asthmatic epithelial cells in response to rhinovirus infection.
BACKGROUND Rhinoviruses (RV) are the most common acute triggers of asthma, and airway epithelial cells are the primary site of… (More)
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2014
2014
PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses.
3-phosphoinositide-dependent protein kinase 1 (PDK1), a member of the protein A,G and C (AGC) family of proteins, is a Ser/Thr… (More)
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Highly Cited
2009
Highly Cited
2009
Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and…
TANK-binding kinase 1 (TBK1) and IkappaB kinase epsilon (IKKepsilon) regulate the production of Type 1 interferons during… (More)
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