Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

BX795

 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

PyrimidinesThiophenes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye
A kinase inhibitor shows promise as a topical antiviral against ocular herpes. Herpes tanked by a kinase inhibitor Interferon… Expand
2018
2018
The cardenolide ouabain suppresses coronaviral replication via augmenting a Na+/K+-ATPase-dependent PI3K_PDK1 axis signaling
&NA; Cardenolides are plant‐derived toxic substances. Their cytotoxicity and the underlying mechanistic signaling axes have been… Expand
  • figure 2
  • table 1
  • table 2
  • figure 3
  • figure 4
2018
2018
Activation of stimulator of interferon genes (STING) induces ADAM17-mediated shedding of the immune semaphorin SEMA4D
Stimulator of interferon genes (STING) is an endoplasmic reticulum–resident membrane protein that mediates cytosolic pathogen DNA… Expand
2015
2015
BX795, a TBK1 inhibitor, exhibits antitumor activity in human oral squamous cell carcinoma through apoptosis induction and mitotic phase arrest.
TANK-binding kinase 1 (TBK1), a member of IκB Kinase (IKK)-related kinases, plays a role in regulating innate immunity… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
2015
2015
Fatty acid synthesis and NLRP3-inflammasome
Fatty acid synthesis is an important process of the lipogenesis [1]. Fatty acid synthesis is tightly regulated by key enzymes… Expand
Highly Cited
2014
Highly Cited
2014
TLR3 and MDA5 signalling, although not expression, is impaired in asthmatic epithelial cells in response to rhinovirus infection.
Rhinoviruses (RV) are the most common acute triggers of asthma, and airway epithelial cells are the primary site of infection… Expand
2014
2014
PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses.
3-phosphoinositide-dependent protein kinase 1 (PDK1), a member of the protein A,G and C (AGC) family of proteins, is a Ser/Thr… Expand
Highly Cited
2012
Highly Cited
2012
Inhibition of intracellular antiviral defense mechanisms augments lentiviral transduction of human natural killer cells: implications for gene therapy.
Adoptive immunotherapy with genetically modified natural killer (NK) cells is a promising approach for cancer treatment. Yet… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
2012
2012
Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.
The design, synthesis and structure-activity relationships of a novel series of 2,4-diamino-5-cyclopropyl pyrimidines is… Expand
  • figure 1
  • table 1
  • figure 2
  • table 2
  • figure 3
Highly Cited
2009
Highly Cited
2009
Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and…
TANK-binding kinase 1 (TBK1) and IkappaB kinase epsilon (IKKepsilon) regulate the production of Type 1 interferons during… Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE