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BX795

National Institutes of Health

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2 relations

Broader (2)

PyrimidinesThiophenes

Papers overview

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2020
2020
The kinase inhibitor BX795 suppresses the inflammatory response via multiple kinases.
2020
2020
In Vitro and In Vivo Activity, Tolerability, and Mechanism of Action of BX795 as an Antiviral against Herpes Simplex Virus 2 Genital Infection
Herpes simplex virus type 2 (HSV-2) causes recurrent lesions in the anogenital area that may be transmitted through sexual… 
Highly Cited
2018
Highly Cited
2018
An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye
A kinase inhibitor shows promise as a topical antiviral against ocular herpes. Herpes tanked by a kinase inhibitor Interferon… 
2018
2018
The cardenolide ouabain suppresses coronaviral replication via augmenting a Na+/K+-ATPase-dependent PI3K_PDK1 axis signaling
Highly Cited
2014
Highly Cited
2014
TLR3 and MDA5 signalling, although not expression, is impaired in asthmatic epithelial cells in response to rhinovirus infection.
Rhinoviruses (RV) are the most common acute triggers of asthma, and airway epithelial cells are the primary site of infection… 
Highly Cited
2013
Highly Cited
2013
PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses
Summary 3-phosphoinositide-dependent protein kinase 1 (PDK1), a member of the protein A,G and C (AGC) family of proteins, is a… 
2013
2013
Interferon regulatory factor 3 activation mediates viral stimulus-induced bronchial production of thymic stromal lymphopoietin.
  • L. Uller
  • Journal of Allergy and Clinical Immunology
  • 2013
  • Corpus ID: 26724246
2012
2012
Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.
Highly Cited
2012
Highly Cited
2012
Inhibition of intracellular antiviral defense mechanisms augments lentiviral transduction of human natural killer cells: implications for gene therapy.
Adoptive immunotherapy with genetically modified natural killer (NK) cells is a promising approach for cancer treatment. Yet… 
Highly Cited
2009
Highly Cited
2009
Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and…
TANK-binding kinase 1 (TBK1) and IkappaB kinase epsilon (IKKepsilon) regulate the production of Type 1 interferons during… 
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