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A Novel Role for 3-O-Sulfated Heparan Sulfate in Herpes Simplex Virus 1 Entry
Herpes simplex virus type 1 (HSV-1) binds to cells through interactions of viral glycoproteins gB and gC with heparan sulfate chains on cell surface proteoglycans. This binding is not sufficient forExpand
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Herpes simplex epithelial and stromal keratitis: an epidemiologic update.
Herpes simplex virus (HSV) is associated with a variety of ocular diseases, including epithelial and stromal keratitis. HSV can cause stromal opacification and is believed to be the leading cause ofExpand
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Herpesviruses and heparan sulfate: an intimate relationship in aid of viral entry.
  • D. Shukla, P. Spear
  • Biology, Medicine
  • The Journal of clinical investigation
  • 15 August 2001
Glycosaminoglycan chains on cell surface proteoglycans provide initial docking sites for the binding to eukaryotic cells of various viruses and other microorganisms. The ubiquitously expressedExpand
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Heparan Sulfate 3-O-Sulfotransferase Isoform 5 Generates Both an Antithrombin-binding Site and an Entry Receptor for Herpes Simplex Virus, Type 1*
  • G. Xia, J. Chen, +5 authors J. Liu
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 4 October 2002
Heparan sulfate 3-O-sulfotransferase transfers sulfate to the 3-OH position of a glucosamine residue of heparan sulfate (HS) to form 3-O-sulfated HS. The 3-O-sulfated glucosamine residue contributesExpand
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Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry
Herpes simplex virus type‐1 and type‐2 are highly prevalent human pathogens causing life‐long infections. The process of infection begins when the virions bind heparan sulfate moieties present onExpand
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Mutations in the N Termini of Herpes Simplex Virus Type 1 and 2 gDs Alter Functional Interactions with the Entry/Fusion Receptors HVEM, Nectin-2, and 3-O-Sulfated Heparan Sulfate but Not with Nectin-1
ABSTRACT Multiple cell surface molecules (herpesvirus entry mediator [HVEM], nectin-1, nectin-2, and 3-O-sulfated heparan sulfate) can serve as entry receptors for herpes simplex virus type 1 (HSV-1)Expand
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Regulation of Notch signaling by Drosophila heparan sulfate 3-O sulfotransferase
Heparan sulfate (HS) regulates the activity of various ligands and is involved in molecular recognition events on the cell surface and in the extracellular matrix. Specific binding of HS to differentExpand
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A novel role for phagocytosis-like uptake in herpes simplex virus entry.
It is becoming increasingly clear that herpesviruses can exploit the endocytic pathway to infect cells, yet several important features of this process remain poorly defined. Using herpes simplexExpand
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Characterization of heparan sulphate 3-O-sulphotransferase isoform 6 and its role in assisting the entry of herpes simplex virus type 1.
Heparan sulphate (HS) 3-O-sulphotransferase transfers sulphate to the 3-OH position of the glucosamine residue of HS to form 3-O-sulphated HS. The HS modified by 3-O-sulphotransferase isoform 3 bindsExpand
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Herpes simplex virus infects most cell types in vitro: clues to its success
Herpes simplex virus (HSV) type-1 and type-2 have evolved numerous strategies to infect a wide range of hosts and cell types. The result is a very successful prevalence of the virus in the humanExpand
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