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BR96 sFv-PE40
A single-chain immunotoxin consisting of Fv fragments of the BR96 monoclonal antibody (MoAb) and a truncated Pseudomonas exotoxin (PE40) that lacking…
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National Institutes of Health
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Related topics
Related topics
3 relations
Narrower (1)
BMS-191352 protein, recombinant
Broader (2)
Monoclonal Antibodies
Recombinant Fusion Proteins
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Clinical evaluation of BR96 sFv-PE40 immunotoxin therapy in canine models of spontaneously occurring invasive carcinoma.
C. Henry
,
Michael S. Buss
,
+4 authors
C. Siegall
Clinical Cancer Research
2005
Corpus ID: 10361595
PURPOSE The immunotoxin BR96 sFv-PE40 is an effective antitumor agent against human breast and lung carcinoma xenografts in…
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Highly Cited
2002
Highly Cited
2002
A phase I trial of the single-chain immunotoxin SGN-10 (BR96 sFv-PE40) in patients with advanced solid tumors.
J. Posey
,
M. Khazaeli
,
+9 authors
M. Saleh
Clinical Cancer Research
2002
Corpus ID: 2500135
PURPOSE Our purpose in the study was to establish the maximum tolerated dose and toxicity profile of SGN-10 (or BR96 sFv-PE40), a…
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Review
1998
Review
1998
Single-chain immunotoxins targeted to CD40 for the treatment of human B-lineage hematologic malignancies.
J. A. Francisco
,
C. Siegall
Leukemia and Lymphoma
1998
Corpus ID: 6663586
Immunotoxins, in chemical conjugate form, have shown limited efficacy in clinical trials in patients with hematologic…
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1997
1997
In vivo efficacy and toxicity of a single-chain immunotoxin targeted to CD40.
J. A. Francisco
,
George J. Schreiber
,
+5 authors
C. Siegall
Blood
1997
Corpus ID: 2438178
G28-5 sFv-PE40 is a single-chain immunotoxin targeted to CD40, which is highly expressed on human hematologic malignancies…
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1995
1995
Activity of a single-chain immunotoxin that selectively kills lymphoma and other B-lineage cells expressing the CD40 antigen.
J. A. Francisco
,
L. Gilliland
,
M. Stebbins
,
N. Norris
,
J. Ledbetter
,
C. Siegall
Cancer Research
1995
Corpus ID: 2261505
We have constructed anti-CD40 immunotoxins consisting of the single chain Fv (sFv) region of the anti-human CD40 mAb G28-5 fused…
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Review
1995
Review
1995
Targeted therapy of carcinomas using BR96 sFv-PE40, a single-chain immunotoxin that binds to the Le(y) antigen.
C. Siegall
Seminars in Cancer Biology
1995
Corpus ID: 35177908
Monoclonal antibody BR96 recognizes a Le(y)-related carbohydrate antigen expressed on a wide range of carcinomas. Immunotoxins…
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Highly Cited
1993
Highly Cited
1993
Antitumor activity of the single-chain immunotoxin BR96 sFv-PE40 against established breast and lung tumor xenografts.
P. Friedman
,
D. Chace
,
P. Trail
,
C. Siegall
Journal of Immunology
1993
Corpus ID: 39606552
We have constructed a single-chain immunotoxin consisting of the variable H and L chains of the carcinoma-reactive mAb BR96…
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Highly Cited
1993
Highly Cited
1993
BR96 sFv-PE40, a potent single-chain immunotoxin that selectively kills carcinoma cells.
P. Friedman
,
Stephen McAndrew
,
+4 authors
C. Siegall
Cancer Research
1993
Corpus ID: 1543497
We have constructed a single-chain immunotoxin composed of the carcinoma-reactive antibody BR96 and a truncated form of…
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