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BN 50739

Known as: 4H-Pyrido(4',3':4,5)thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine, 6-(2-chlorophenyl)-9-(2-((3,4-dimethoxyphenyl)thio)-1-thioxoethyl)-7,8,9,10-tetrahydro-1-methyl-, BN-50739 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

Anti-Arrhythmia AgentsAzepinesTriazoles

Papers overview

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2006
2006
Nupafant, a PAF‐antagonist prototype for suppression of ventricular fibrillation without liability for QT prolongation?
PAF antagonists inhibit ischaemia‐induced ventricular fibrillation (VF) in animals. However, unfavourable ancillary actions (on… 
2004
2004
Left regional cardiac perfusion in vitro with platelet‐activating factor, norepinephrine and K+ reveals that ischaemic arrhythmias are caused by independent effects of endogenous ‘mediators…
Various putative drug targets for suppression of ischaemia‐induced ventricular fibrillation (VF) have been proposed, but… 
1999
1999
Protection against ventricular fibrillation by the PAF antagonist, BN-50739, involves an ischaemia-selective mechanism.
The platelet-activating factor (PAF) antagonist BN-50739 can suppress certain cardiac arrhythmias. PAF is released from ischaemic… 
1994
1994
Effect of the Platelet‐Activating Factor Antagonist BN 50739 and Its Diluents on Mitochondrial Respiration and Membrane Lipids During and Following Cerebral Ischemia
Abstract: Recent evidence suggests that platelet‐activating factor plays a role in ischemia‐induced neural injury. The Pulsinelli… 
1994
1994
Platelet activating factor impairs pressor responses to noradrenaline in the anaesthetized rat but does not mediate endotoxin-induced hyporeactivity.
A nonhypotensive dose of endotoxin (Escherichia coli lipopolysaccharide, 250 micrograms kg-1 h-1) impaired both the pressor… 
1993
1993
BN-50739: a PAF antagonist and limitation of myocardial infarct size.
Anesthetized rats were subjected to coronary artery ligation (CAL) for 72 h and infarct size was measured macroscopically using… 
1991
1991
Effect of BN 50739, a new platelet activating factor antagonist, on ischaemia induced ventricular arrhythmias in isolated working rat hearts.
STUDY OBJECTIVE The aim was to investigate the role of platelet activating factor (PAF) in myocardial ischaemia by using BN 50739… 
1991
1991
Inhibitory effect of new PAF antagonists on PAF-induced rabbit platelet aggregation in vitro and ex vivo.
The effect of BN 50739, a recently developed PAF antagonist, on PAF-induced rabbit platelet aggregation in vitro and ex vivo was… 
1990
1990
Biological responses to liposome-encapsulated hemoglobin (LEH) are improved by a PAF antagonist.
Liposome-encapsulated hemoglobin (LEH) is an experimental oxygen-carrying blood substitute. Previous studies in our laboratory… 
1990
1990
Beneficial actions of BN 50739, a new PAF receptor antagonist, in murine traumatic shock.
We studied the effects of BN 50739, a novel PAF antagonist, in a rat model of traumatic shock. Pentobarbital anesthetized rats… 
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