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BI 836845

Known as: IGF Ligand Neutralizing Antibody BI 836845 
A humanized IgG1 insulin-like growth factor (IGF) monoclonal antibody targeting the IGF ligands 1 (IGF-1) and 2 (IGF-2), with potential… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Antibodies, Neutralizing
antigen binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Statistical modelling and analysis of the infection dynamics of PRRSV in vivo infections
Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically significant viral diseases facing the global… 
2017
2017
P3.02b-005 Phase Ib Trial of Afatinib and BI 836845 in Advanced NSCLC: Dose Escalation and Safety Results: Topic: EGFR Biomarkers
2016
2016
Phase 1b/2 trial of BI 836845, an insulin-like growth factor (IGF) ligand-neutralizing antibody, combined with exemestane (Ex) and everolimus (Ev) in hormone receptor-positive (HR+) locally advanced…
530Background: BI 836845, an IGF ligand-neutralizing antibody, binds IGF-1 and IGF-2, inhibits growth-promoting signaling and… 
2016
2016
Phase I dose escalation (esc) trial of weekly intravenous (i.v.) BI 836845 in Japanese patients (pts) with advanced solid tumors
2014
2014
Quantification of binding of IGF-1 to BI 836845, a candidate therapeutic antibody against IGF-1 and IGF-2, and effects of this antibody on IGF-1:IGFBP-3 complexes in vitro and in male C57BL/6 mice.
IGF-1 and IGF-2 are potent mitogens acting through the IGF-1 receptor (IGF-1R). The importance of the IGF system in neoplasia has… 
2014
2014
A phase I dose escalation study of weekly BI 836845, a fully human, affinity-optimized, insulin-like growth factor (IGF) ligand neutralizing antibody, in patients with advanced solid cancers.
2617 Background: The IGF signaling pathway has an important role in neoplasia and is associated with cancer progression… 
1996
1996
Hydration of C-H groups in tRNA.
Molecular dynamic (MD) simulations of the anticodon hairpin of tRNA(Asp) and of the full tRNA, both in a solvent bath with… 
Highly Cited
1995
Highly Cited
1995
The glycoprotein of viral hemorrhagic septicemia virus (VHSV): antigenicity and role in virulence.
In order to study the antigenic structure of the G protein of VHSV, we produced several anti-G monoclonal antibodies (MAbs) and… 
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