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BD 1047

Known as: BD-1047, BD1047 
National Institutes of Health

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Ethylenediamines

Papers overview

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2015
2015
Spinal sigma-1 receptor activation increases the production of D-serine in astrocytes which contributes to the development of mechanical allodynia in a mouse model of neuropathic pain.
2014
2014
Sigma-1 receptor antagonist, BD1047 reduces nociceptive responses and phosphorylation of p38 MAPK in mice orofacial formalin model.
Sigma-1 receptors (Sig-1Rs) play a role in different types of pain and in central sensitization mechanism in spinal cord. However… 
2014
2014
Sigma-1 Receptor Antagonism Restores Injury-Induced Decrease of Voltage-Gated Ca2+ Current in Sensory Neurons
Sigma-1 receptor (σ1R), an endoplasmic reticulum–chaperone protein, can modulate painful response after peripheral nerve injury… 
2013
2013
Sigma-1 receptor-mediated increase in spinal p38 MAPK phosphorylation leads to the induction of mechanical allodynia in mice and neuropathic rats
2011
2011
Fluvoxamine enhances prefrontal dopaminergic neurotransmission in adrenalectomized/castrated mice via both 5-HT reuptake inhibition and σ1 receptor activation
RationaleFluvoxamine, a selective serotonin (5-HT) reuptake inhibitor (SSRI) and an agonist for the σ1 receptors, increases… 
2008
2008
Emergence of NMDAR‐independent long‐term potentiation at hippocampal CA1 synapses following early adolescent exposure to chronic intermittent ethanol: Role for sigma‐receptors
Adolescent humans who abuse alcohol are more vulnerable than adults to the development of memory impairments. Memory impairments… 
2007
2007
Stereoselective action of (+)-morphine over (-)-morphine in attenuating the (-)-morphine-produced antinociception via the naloxone-sensitive sigma receptor in the mouse.
2007
2007
Novel sigma (sigma) receptor agonists produce antidepressant-like effects in mice.
Many antidepressant drugs interact with sigma receptors and accumulating evidence suggests that these proteins mediate… 
2005
2005
Sigma receptor antagonists inhibit human lens cell growth and induce pigmentation.
PURPOSE The expression of the Sigma 1 receptor and the ability of receptor antagonists to inhibit growth and induce pigment… 
2003
2003
Metabolism to dextrorphan is not essential for dextromethorphan's anticonvulsant activity against kainate in mice.
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