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BCR gene

Known as: BCR, D22S662, ALL 
This gene plays a role in signal transduction.
National Institutes of Health

Related topics

Related topics

8 relations
BCR protein, humanBCR wt AlleleBCRP2 genePhiladelphia Chromosome

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
A comprehensive target selectivity survey of the BCR-ABL kinase inhibitor INNO-406 by kinase profiling and chemical proteomics in chronic myeloid leukemia cells
Resistance to the BCR-ABL tyrosine kinase inhibitor imatinib poses a pressing challenge in treating chronic myeloid leukemia (CML… 
Highly Cited
2001
Highly Cited
2001
A translocation breakpoint cluster disrupts the newly defined 3' end of the SNURF-SNRPN transcription unit on chromosome 15.
Balanced translocations affecting the paternal copy of 15q11--q13 are a rare cause of Prader-Willi syndrome (PWS) or PWS-like… 
Review
1996
Review
1996
Cytogenetics and molecular genetics of carcinomas arising from thyroid epithelial follicular cells
Cytogenetic and molecular analyses of thyroid tumors have indicated that these neoplasms represent a good model for analyzing… 
Highly Cited
1993
Highly Cited
1993
BCR-ABL gene rearrangement and expression of primitive hematopoietic progenitors in chronic myeloid leukemia.
Chronic myeloid leukemia (CML) is characterized by an initial chronic phase of expanded yet orderly clonal hematopoiesis that is… 
Highly Cited
1991
Highly Cited
1991
Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor.
Phosphotyrosine cannot be detected on normal human ABL protein-tyrosine kinases, but activated oncogenic forms of the human ABL… 
Highly Cited
1991
Highly Cited
1991
A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14).
The translocation t(10;14)(q24;q11) is an acquired change seen in 4% to 7% of T-cell acute lymphoblastic leukemias (T-ALL). We… 
Review
1991
Review
1991
Does the breakpoint within the major breakpoint cluster region (M-bcr) influence the duration of the chronic phase in chronic myeloid leukemia? An analytical comparison of current literature.
Highly Cited
1989
Highly Cited
1989
Nucleotide sequence of both reciprocal translocation junction regions in a patient with Ph positive acute lymphoblastic leukaemia, with a breakpoint within the first intron of the BCR gene.
Breakpoints on chromosome 22 in the translocation t(9;22) found in Philadelphia positive acute lymphoblastic leukaemia patients… 
Highly Cited
1987
Highly Cited
1987
Recombination at the human alpha-globin gene cluster: sequence features and topological constraints.
We have characterized 170 kb of DNA around the human alpha-globin gene cluster to enable a systematic analysis of 12 naturally… 
Review
1986
Review
1986
Rearrangement in the breakpoint cluster region and the clinical course in Philadelphia-negative chronic myelogenous leukemia.
We have followed one patient with Philadelphia (Ph)-negative chronic myelogenous leukemia and identified an additional four… 
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