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BCR protein, human

Known as: BCR1, ALL, CML 
The 160 kD BCR phosphoprotein exhibits a unique serine/threonine kinase activity, at least two SH2 binding sites, and a C-terminal GTPase activating… 
National Institutes of Health

Related topics

Related topics

12 relations
Acute lymphocytic leukemiaB-cell receptor complex locationBCR geneBCR wt Allele

Broader (1)

Proto-Oncogene Proteins c-bcr

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
OPTIMIZATION AND IN VITRO EVALUATION OF 5-FLUOROURACIL – LOADED LONG – CIRCULATING LIPOSOMES
5-Fluorouracil (5-FU) is an anticancer drug widely used in the treatment of colorectal cancers. In this work, long-circulating… 
2017
2017
CT-721, a Potent Bcr-Abl Inhibitor, Exhibits Excellent In Vitro and In Vivo Efficacy in the Treatment of Chronic Myeloid Leukemia
Kinase inhibitors that target Bcr-Abl are highly effective in the treatment of chronic myeloid leukemia (CML). However, these… 
2017
2017
Computing time dependent travel times in vehicle routing problems
Motivation: One of the products delivered by ORTEC is a software suite called ORTEC Routing & Dispatch (ORD), which manages and… 
2014
2014
Clinical application of catalytically cleavable fluorescence probe technology for multiplexing quantification of BCR-ABL1 fusion transcripts.
BACKGROUND Accurate measurement of BCR-ABL1 fusion transcripts is critical for therapeutic stratification in patients with… 
2005
2005
of Chronic Myelogenous Leukemia Cells Degradation and ProliferationKip 1 Pathway to Promote p 27 BCR-ABL Induces the Expression of Skp 2 through the PI 3 K Updated
Chronic myelogenous leukemia (CML) is characterized by the expression of the BCR-ABL tyrosine kinase, which results in increased… 
2005
2005
Modulation of the p 38 MAPK ( mitogen-activated protein kinase ) pathway through Bcr / Abl : implications in the cellular response to AraC
Vı́ctor Javier SÁNCHEZ-ARÉVALO LOBO*, Clara Isabel ACEVES LUQUERO†, Luis ÁLVAREZ-VALLINA*, Alex J. TIPPING‡, Juan Guinea VINIEGRA… 
2003
2003
A Tumor (GIST), a Mutated Gene (c-kit), and a Molecular Inhibitor (Imatinib)" Insights from Computer Simulations
Deregulation of c-kit has been implicated in the etiology of a number of cancers, including gastrointestinal stromal tumors… 
Review
2003
Review
2003
Advances in Brief A Novel Pyridopyrimidine Inhibitor of Abl Kinase Is a Picomolar Inhibitor of Bcr-abl-driven K 562 Cells and Is Effective against STI 571-resistant Bcr-abl Mutants 1
Inhibition of the constitutively active Bcr-abl tyrosine kinase (TK) by STI571 has proven to be a highly effective treatment for… 
1999
1999
Links the Bcr-Abl Oncogene and Ras to the Stress-Activated Protein Kinase Pathway
The Bcr-Abl oncogene, found in Philadelphia chromosomepositive myelogenous leukemia (CML), activates Ras and triggers the stress… 
1987
1987
RFLP detected with a 5'-bcr-gene-sequence (HGM8 provisional no. D22S11).