Philadelphia Chromosome

Known as: Chromosome, Philadelphia, Ph 1 Chromosomes, Philadelphia Chromosome [Disease/Finding] 
An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
BACKGROUND Ponatinib is a potent oral tyrosine kinase inhibitor of unmutated and mutated BCR-ABL, including BCR-ABL with the… (More)
  • table 2
  • table 3
  • table 4
Is this relevant?
Highly Cited
2012
Highly Cited
2012
BACKGROUND Resistance to tyrosine kinase inhibitors in patients with chronic myeloid leukemia (CML) and Philadelphia chromosome… (More)
  • table 1
  • table 2
  • table 2
  • table 3
  • table 3
Is this relevant?
Highly Cited
2011
Highly Cited
2011
BACKGROUND Nilotinib has shown greater efficacy than imatinib in patients with newly diagnosed Philadelphia chromosome-positive… (More)
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Blast crisis chronic myelogenous leukemia (CML-BC) and Philadelphia chromosome-positive (Ph1-positive) acute lymphocytic leukemia… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2006
Highly Cited
2006
BACKGROUND The BCR-ABL tyrosine kinase inhibitor imatinib is effective in Philadelphia chromosome-positive (Ph-positive… (More)
  • table 1
  • table 2
  • table 2
  • table 3
  • figure 1
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Imatinib mesylate, an inhibitor of the Bcr-Abl tyrosine kinase, has modest activity in refractory/relapsed Philadelphia… (More)
  • table 1
  • table 2
  • table 2
  • table 2
  • figure 1
Is this relevant?
Highly Cited
2001
Highly Cited
2001
BACKGROUND BCR-ABL, a constitutively activated tyrosine kinase, is the product of the Philadelphia chromosome. This enzyme is… (More)
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
1995
Highly Cited
1995
The BCR/ABL oncogenic tyrosine kinase is responsible for initiating and maintaining the leukemic phenotype of Philadelphia… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?
Highly Cited
1990
Highly Cited
1990
In tumor cells from virtually all patients with chronic myelogenous leukemia, the Philadelphia chromosome, a fusion of… (More)
Is this relevant?
Highly Cited
1983
Highly Cited
1983
The localization of cellular oncogenes near the break points of tumour-specific chromosomal aberrations suggests an involvement… (More)
Is this relevant?