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Aurora Kinases

Known as: Aurora Kinases [Chemical/Ingredient] 
A family of highly conserved serine-threonine kinases that are involved in the regulation of MITOSIS. They are involved in many aspects of cell… 
National Institutes of Health

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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Functional Effects of AKT3 on Aurora Kinase Inhibitor-induced Aneuploidy*
The suppression of mitotic Aurora kinases (AURKs) by AURK inhibitors frequently causes cytokinetic failure, leading to polyploidy… 
2015
2015
Selective inhibitors of aurora kinases inhibit proliferation, reduce cell viability and impair cell cycle progression in papillary thyroid carcinoma cells.
The three members of the Aurora kinase family, Aurora-A, -B and -C, regulate several aspects of the mitotic process, and their… 
2014
2014
Hypersensitivity to aurora kinase inhibitors in cells resistant against platinum- containing anticancer agents.
The aurora kinases are serine/threonine kinases that are essential for mitosis and contribute to tumorigenesis. Therefore, aurora… 
2013
2013
Hydrosoluble Benzo[e]pyridoindolones as Potent Inhibitors of Aurora Kinases
Aurora kinases play an essential role in mitotic progression and are potentially druggable targets in cancer therapy. We… 
2012
2012
Targeting aurora kinases: a novel approach to curb the growth & chemoresistance of androgen refractory prostate cancer.
Aurora Kinase (AK) based therapy targeting AK-A & B is effective against some cancers. We have explored its potential against… 
Review
2009
Review
2009
Small molecule aurora kinases inhibitors.
Aurora kinases represent one of the emerging targets in oncology drug discovery. These kinases play important role in centrosome… 
Review
2005
Review
2005
Progress in the development of selective inhibitors of aurora kinases.
Errors in the mitotic process are thought to be one of the principal sources of the genetic instability that hallmarks cancer… 
2004
2004
Aurora kinases dawn as cancer drug targets
A new anticancer compound interferes with aurora kinases, regulators of mitosis. We can now hope for the biology of these kinases… 
2003
2003
Targeting aurora2 kinase in oncogenesis: a structural bioinformatics approach to target validation and rational drug design.
The aurora kinases are a novel oncogenic family of mitotic serine/threonine kinases (S/T kinases) that are overexpressed in a… 
Review
2001
Review
2001
Two Mammalian Mitotic Aurora Kinases: Who's Who?
Several serine-threonine kinases related to the Ipl1p kinase in budding yeast, termed aurora kinases, have been cloned recently… 
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