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Attenuation

Known as: Attenuate, Attenuated 
A weakening in force or intensity.
National Institutes of Health

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Papers overview

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2017
2017
Genetic characteristics, pathogenicity, and immunogenicity associated with cell adaptation of a virulent genotype 2b porcine epidemic diarrhea virus
Review
2015
Review
2015
Reverse genetics of Mononegavirales: How they work, new vaccines, and new cancer therapeutics.
Highly Cited
2008
Highly Cited
2008
Virus-specific intestinal IFN-gamma producing T cell responses induced by human rotavirus infection and vaccines are correlated with protection against rotavirus diarrhea in gnotobiotic pigs.
Highly Cited
2005
Highly Cited
2005
Multiple Gene Segments Control the Temperature Sensitivity and Attenuation Phenotypes of ca B/Ann Arbor/1/66
ABSTRACT Cold-adapted (ca) B/Ann Arbor/1/66 is the influenza B virus strain master donor virus for FluMist, a live, attenuated… 
Highly Cited
2003
Highly Cited
2003
Multiple amino acid residues confer temperature sensitivity to human influenza virus vaccine strains (FluMist) derived from cold-adapted A/Ann Arbor/6/60.
Highly Cited
1999
Highly Cited
1999
Identification of Mutations Contributing to the Temperature-Sensitive, Cold-Adapted, and Attenuation Phenotypes of the Live-Attenuated Cold-Passage 45 (cp45) Human Parainfluenza Virus 3 Candidate…
ABSTRACT The live-attenuated human parainfluenza virus 3 (PIV3) cold-passage 45 (cp45) candidate vaccine was shown previously to… 
Highly Cited
1998
Highly Cited
1998
Three Amino Acid Substitutions in the L Protein of the Human Parainfluenza Virus Type 3 cp45 Live Attenuated Vaccine Candidate Contribute to Its Temperature-Sensitive and Attenuation Phenotypes
ABSTRACT Studies were initiated to define the genetic basis of the temperature-sensitive (ts), cold adaptation (ca), and… 
Highly Cited
1993
Highly Cited
1993
Rescue of an influenza A virus wild-type PB2 gene and a mutant derivative bearing a site-specific temperature-sensitive and attenuating mutation
Live attenuated influenza A virus vaccines are currently produced by the transfer of attenuating genes from a donor virus to new… 
1990
1990
A 36 nucleotide deletion mutation in the coding region of the NS1 gene of an influenza A virus RNA segment 8 specifies a temperature-dependent host range phenotype.
Highly Cited
1988
Highly Cited
1988
Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccines
Clinical studies previously demonstrated that live influenza A virus vaccines derived by genetic reassortment from the mating of… 
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