Atovaquone

Known as: 3-(4-(4-chlorophenyl)cyclohexyl)-4-hydroxy-naphthalene-1,2-dione, 2-(trans-4-(4-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone, 2-(4-(4'-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone 
A synthetic hydroxynaphthoquinone with antiprotozoal activity. Atovoquone blocks the mitochondrial electron transport at complex III of the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1992-2018
0204019922018

Papers overview

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2006
2006
Plasmodium falciparum resistance to atovaquone-proguanil has so far been associated with Y268S or Y268N mutations in cytochrome b… (More)
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2004
Highly Cited
2004
A modified fixed-ratio isobologram method for studying the in vitro interactions between antiplasmodial drugs is described. This… (More)
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Highly Cited
2001
Highly Cited
2001
Concerns about the tolerability of mefloquine highlight the need for new drugs to prevent malaria. Atovaquone-proguanil (Malarone… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Babesiosis is a tick-borne, malaria-like illness known to be enzootic in southern New England. A course of clindamycin… (More)
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Highly Cited
2000
Highly Cited
2000
Atovaquone is the major active component of the new antimalarial drug Malarone. Considerable evidence suggests that malaria… (More)
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Highly Cited
1999
Highly Cited
1999
Atovaquone represents a class of antimicrobial agents with a broad-spectrum activity against various parasitic infections… (More)
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Highly Cited
1997
Highly Cited
1997
At present, approaches to studying mitochondrial functions in malarial parasites are quite limited because of the technical… (More)
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Highly Cited
1996
Highly Cited
1996
The therapy of Plasmodium falciparum malaria continues to be a problem in many parts of Southeast Asia because of multidrug… (More)
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1996
1996
BACKGROUND The increasing spread of multidrug-resistant Plasmodium falciparum malaria emphasises the urgent need for alternative… (More)
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Highly Cited
1995
Highly Cited
1995
A series of Plasmodium falciparum in vitro drug sensitivity studies were conducted in order to evaluate atovaquone in combination… (More)
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