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Atovaquone

Known as: 3-(4-(4-chlorophenyl)cyclohexyl)-4-hydroxy-naphthalene-1,2-dione, 2-(trans-4-(4-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone, 2-(4-(4'-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone 
A synthetic hydroxynaphthoquinone with antiprotozoal activity. Atovoquone blocks the mitochondrial electron transport at complex III of the… 
National Institutes of Health

Related topics

Related topics

30 relations

Narrower (6)

566C566C80Atovaquone / ProguanilBW-566C

Broader (6)

Anti-Infective AgentsAntifungal AgentsAntimalarialsAntiparasitic Agents
Antiprotozoal AgentsAtovaquone 150 MG/ML Oral Suspension [Mepron]Atovaquone 250 MG / proguanil hydrochloride 100 MG Oral TabletAtovaquone 62.5 MG / proguanil hydrochloride 25 MG Oral Tablet [Malarone]

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action
Atovaquone, a substituted hydroxynaphthoquinone, is a potent antimalarial drug that acts by inhibiting the parasite’s… 
Review
2008
Review
2008
Potential antimalarial activity of indole alkaloids.
Review
2006
Review
2006
Metabolic maps and functions of the Plasmodium mitochondrion.
The mitochondrion of Plasmodium species is a validated drug target. However, very little is known about the functions of this… 
Review
2002
Review
2002
Antiparasitic Agent Atovaquone
Atovaquone is a unique naphthoquinone with broad-spectrum antiprotozoal activity. It is effective for the treatment and… 
Highly Cited
2000
Highly Cited
2000
Atovaquone and azithromycin for the treatment of babesiosis.
BACKGROUND Babesiosis is a tick-borne, malaria-like illness known to be enzootic in southern New England. A course of clindamycin… 
Highly Cited
2000
Highly Cited
2000
Plasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during five years of extensive use of artesunate-mefloquine.
Highly Cited
1997
Highly Cited
1997
Variations in frequencies of drug resistance in Plasmodium falciparum.
Continual exposure of malarial parasite populations to different drugs may have selected not only for resistance to individual… 
Highly Cited
1995
Highly Cited
1995
Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro.
A series of Plasmodium falciparum in vitro drug sensitivity studies were conducted in order to evaluate atovaquone in combination… 
Highly Cited
1995
Highly Cited
1995
Interconnection between organellar functions, development and drug resistance in the protozoan parasite, Toxoplasma gondii.
Highly Cited
1993
Highly Cited
1993
Comparison of atovaquone (566C80) with trimethoprim-sulfamethoxazole to treat Pneumocystis carinii pneumonia in patients with AIDS.
BACKGROUND Both trimethoprim-sulfamethoxazole and pentamidine are effective as treatments for Pneumocystis carinii pneumonia, but… 
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