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Aspartate-Semialdehyde Dehydrogenase

Known as: L-Aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating), Aldehyde Dehydrogenase, Semiaspartate, Dehydrogenase, Aspartate-Semialdehyde 
An enzyme that catalyzes the conversion of L-aspartate 4-semialdehyde, orthophosphate, and NADP+ to yield L-4-aspartyl phosphate and NADPH. EC 1.2.1… Expand
National Institutes of Health

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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Structures of ternary complexes of aspartate-semialdehyde dehydrogenase (Rv3708c) from Mycobacterium tuberculosis H37Rv.
Aspartate-semialdehyde dehydrogenase (Asd; ASADH; EC 1.2.1.11) is the enzyme that lies at the first branch point in the… Expand
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2005
2005
Design, Synthesis and Analysis of Inhibitors of Bacterial Aspartate Semialdehyde Dehydrogenase
Unsaturated and fluorinated analogues of aspartyl‐β‐phosphate were synthesised as potential inhibitors of the bacterial enzyme… Expand
2004
2004
Aspartokinase genes lysCα and lysCβ overlap and are adjacent to the aspartate β-semialdehyde dehydrogenase gene asd in Corynebacterium glutamicum
SummaryA 2.1 kb DNA fragment of the recombinant plasmid pCS2, isolated from an aminoethyl cysteine (AEC)-resistant and lysine… Expand
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Highly Cited
2004
Highly Cited
2004
Cystathionine β-Lyase Is Important for Virulence of Salmonella enterica Serovar Typhimurium
ABSTRACT The biosynthesis of methionine in bacteria requires the mobilization of sulfur from Cys by the formation and degradation… Expand
2002
2002
Overproduction, purification, and characterization of recombinant aspartate semialdehyde dehydrogenase from Arabidopsis thaliana.
In plant and microorganisms, aspartate semialdehyde dehydrogenase (ASDH) produces the branch point intermediate between the… Expand
2002
2002
Aspartyl Phosphonates and Phosphoramidates: The First Synthetic Inhibitors of Bacterial Aspartate‐Semialdehyde Dehydrogenase
The synthesis of methylene phosphonate, difluoromethylene phosphonate and phosphoramidate analogues of aspartyl phosphate… Expand
Highly Cited
2001
Highly Cited
2001
Active site analysis of the potential antimicrobial target aspartate semialdehyde dehydrogenase.
Aspartate-beta-semialdehyde dehydrogenase (ASADH) lies at the first branch point in the biosynthetic pathway through which… Expand
Highly Cited
1994
Highly Cited
1994
Isolation and characterization of the aspartokinase and aspartate semialdehyde dehydrogenase operon from mycobacteria
Diaminopimelic acid (DAP) is a major component of the peptidoglycan layer of the mycobacterial cell wall. The mycobacterial cell… Expand
Highly Cited
1991
Highly Cited
1991
Control of the Lysine Biosynthesis Sequence in Corynebacterium glutamicum as Analyzed by Overexpression of the Individual Corresponding Genes
The gene cluster that codes for feedback-resistant aspartate kinase (lysCα and lysCβ) and aspartate semialdehyde dehydrogenase… Expand
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Highly Cited
1982
Highly Cited
1982
Expression of Streptococcus mutans aspartate-semialdehyde dehydrogenase gene cloned into plasmid pBR322.
Streptococcus mutans chromosomal DNA cloned into the vector plasmid pBR322 in Escherichia coli is able to complement the… Expand
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