Apoptosomes

Known as: Apoptosomes [Chemical/Ingredient], Apoptosome, Complex, Apoptosomal Protein 
Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. They can occur when MITOCHONDRIA become damaged… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
Recent work on the initial switches that trigger cell death has revealed surprising inventions of nature that ensure the ordered… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Review
2007
Review
2007
Apoptosome refers to the adaptor protein complex that mediates the activation of an initiator caspase at the onset of apoptosis… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2004
Highly Cited
2004
The Apaf-1 apoptosome is a multi-subunit caspase-activating scaffold that is assembled in response to diverse forms of cellular… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2002
Highly Cited
2002
The apoptosome is an Apaf-1 cytochrome c complex that activates procaspase-9. The three-dimensional structure of the apoptosome… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
Is this relevant?
Review
2002
Review
2002
Activation of the caspases that initiate apoptosis typically requires cognate scaffold proteins, including CED-4 in… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Apoptosis is an evolutionarily conserved cell suicide process executed by cysteine proteases (caspases) and regulated by the… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2000
Highly Cited
2000
The cellular-stress response can mediate cellular protection through expression of heat-shock protein (Hsp) 70, which can… (More)
  • figure 1
  • figure 4
  • figure 3
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Release of cytochrome c from mitochondria by apoptotic signals induces ATP/dATP-dependent formation of the oligomeric Apaf-1… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1999
Highly Cited
1999
We report here the reconstitution of the de novo procaspase-9 activation pathway using highly purified cytochrome c, recombinant… (More)
Is this relevant?
Review
1998
Review
1998
Apoptosis is an essential physiological process for the selective elimination of cells, which is involved in a variety of… (More)
  • figure 9.25
  • table 9.2
  • figure 9.27
  • figure 9.22
  • figure 9.22
Is this relevant?