• Publications
  • Influence
Captopril inhibits angiogenesis and slows the growth of experimental tumors in rats.
TLDR
This widely used drug is defined as a new inhibitor of neovascularization and the possibility that patients on long term captopril therapy may derive unexpected benefits from its antiangiogenic activities is raised. Expand
Estrogen and progesterone receptor concordance between primary and recurrent breast cancer
TLDR
A significantly shorter disease‐free survival (DFS) for patients with ER (p+)/(r‐) (primary receptor positive/recurrent receptor negative) was significantly shorter than those withER (p‐)/( r+)(27.6 ± 7.4 months versus 50.6± 7.6 mo, P=0.04). Expand
Vitamin A deficiency injures lung and liver parenchyma and impairs function of rat type II pneumocytes.
TLDR
Evidence is provided that vitamin A deficiency produces profound morphologic alterations in liver and lung parenchyma and impairs pneumocyte function, as well as in the small arteries and arterioles, but not in the larger ones. Expand
Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreas
TLDR
Although the use of exendin-4 in rats is associated with decreased weight gain, lower insulin resistance and lower leptin levels than in control animals, extended use of the drug in rats leads to pancreatic acinar inflammation and pyknosis, which raises important concerns about the likelihood of inducing acute pancreatitis in humans receiving incretin mimetic therapy. Expand
Effect of an angiotensin II receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-beta (TGF-beta) and alpha-actomyosin (alpha SMA), important mediators of
TLDR
The finding that ACE inhibitors or ANG II receptor blockers protect the lungs from radiation induced pneumonitis and fibrosis reaffirms the role that ANG II plays in this inflammatory process and suggests an additional indication of treatment of this condition, thus opening a new potential pharmacologic use of these drugs. Expand
Effects of Dietary Calorie Restriction or Exercise on the PI3K and Ras Signaling Pathways in the Skin of Mice*
TLDR
DCR abrogated both Ras and PI3K signaling, which might inhibit TPA-induced proliferation and anti-apoptosis and seems more attributable to the magnitude of the caloric deficit and/or body fat loss than diet versus exercise comparison. Expand
Control of radiation-induced pneumopathy and lung fibrosis by angiotensin-converting enzyme inhibitors and an angiotensin II type 1 receptor blocker.
TLDR
ACE inhibitors and one AII type 1 receptor blocker were effective in protecting lungs from radiation-induced pneumonitis and the development of lung fibrosis in two models of rat radiation injury. Expand
Angiotensin-converting enzyme inhibitors: mechanisms of action and implications in anesthesia practice.
TLDR
The role of ACEIs and their possible interaction with anesthetic agents must be an integral part of clinical decision-making during anesthesia Hemodynamic variation during anesthesia is mainly related to specific effects of anesthetic agent on sympathetic nervous system. Expand
Effect of an angiotensin II receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-β (TGF-β) and α-actomyosin (α SMA), important mediators of
TLDR
The finding that ACE inhibitors or ANG II receptor blockers protect the lungs from radiation induced pneumonitis and fibrosis reaffirms the role that ANG II plays in this inflammatory process and suggests an additional indication of treatment of this condition, thus opening a new potential pharmacologic use of these drugs. Expand
Effect of wood combustion smoke inhalation on angiotensin-1-converting enzyme in the dog.
TLDR
Angiotensin-1-converting enzyme activity in biopsied tissue of the smoke-exposed lung was markedly increased immediately after the injury and even higher 30 minutes later, seen as an early response of the lung endothelial cells to many types of injury. Expand
...
1
2
3
4
5
...