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Antifungal Agent F901318

Known as: F901318 
A systemic antifungal agent that can potentially be used in the treatment of systemic fungal infections.
National Institutes of Health

Papers overview

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2020
2020
The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of Aspergillus fumigatus
The first characterized antifungal in the orotomide class is olorofim. It targets the de novo pyrimidine biosynthesis pathway by… 
2019
2019
Efficacy of Olorofim (F901318) against Aspergillus fumigatus, A. nidulans, and A. tanneri in Murine Models of Profound Neutropenia and Chronic Granulomatous Disease
The emergence of azole resistance in Aspergillus fumigatus as well as an increasing frequency of multiresistant cryptic… 
Review
2018
Review
2018
Recent Advances in the Treatment of Scedosporiosis and Fusariosis
Species of Scedosporium and Fusarium are considered emerging opportunistic pathogens, causing invasive fungal diseases in humans… 
Highly Cited
2018
Highly Cited
2018
Effect of the Novel Antifungal Drug F901318 (Olorofim) on Growth and Viability of Aspergillus fumigatus
F901318 (olorofim) is a novel antifungal drug that is highly active against Aspergillus species. Belonging to a new class of… 
2018
2018
The Orotomide Olorofim Is Efficacious in an Experimental Model of Central Nervous System Coccidioidomycosis
Olorofim (formerly F901318) is an advanced analog of the orotomide class that inhibits fungal pyrimidine biosynthesis. We… 
2018
2018
Reliable and Easy-To-Use Liquid Chromatography-Tandem Mass Spectrometry Assay for Quantification of Olorofim (F901318), a Novel Antifungal Drug, in Human Plasma and Serum
A fast and easy-to-use liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination and quantification… 
Highly Cited
2017
Highly Cited
2017
Dihydroorotate dehydrogenase inhibitor F901318 has potent in vitro activity against Scedosporium species and Lomentospora prolificans
Background Scedosporium species and Lomentospora prolificans are increasing causes of invasive infections in immunocompromised… 
2017
2017
Systemic Antifungal Agents: Current Status and Projected Future Developments.
By definition, an antifungal agent is a drug that selectively destroys fungal pathogens with minimal side effects to the host… 
2017
2017
Pharmacodynamics of the Orotomides against Aspergillus fumigatus: New Opportunities for Treatment of Multidrug-Resistant Fungal Disease
ABSTRACT F901318 is an antifungal agent with a novel mechanism of action and potent activity against Aspergillus spp. An… 
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