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ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients.
TLDR
This part of the EFISG guidelines focuses on non-neutropenic adult patients, and liposomal amphotericin B and voriconazole are supported with moderate, and fluconazole with marginal strength for the targeted initial treatment of candidaemia. Expand
Emergence of Azole Resistance in Aspergillus fumigatus and Spread of a Single Resistance Mechanism
TLDR
The presence of a dominant resistance mechanism in clinical isolates suggests that isolates with this mechanism are spreading in the authors' environment, and might be more prevalent than currently acknowledged. Expand
Detection of circulating galactomannan for the diagnosis and management of invasive aspergillosis.
TLDR
Some of the factors that affect the release of the aspergillus antigen that bears the epitope that reacts with the monoclonal antibody used in the ELISA, its leakage from the site of infection into the blood, and its binding to substances present in the blood are explored. Expand
Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.
TLDR
Treatment duration for aspergillosis is strongly recommended based on clinical improvement, degree of immunosuppression and response on imaging, and in refractory disease, where a personalized approach considering reversal of predisposing factors, switching drug class and surgical intervention is also strongly recommended. Expand
Possible Environmental Origin of Resistance of Aspergillus fumigatus to Medical Triazoles
TLDR
It is hypothesized that azole resistance might develop through azole exposure in the environment rather than in azole-treated patients, and it showed that environmental and clinical isolates were genetically clustered apart from nonresistant isolates. Expand
Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research
TLDR
These updated definitions of IFDs should prove applicable in clinical, diagnostic, and epidemiologic research of a broader range of patients at high-risk. Expand
Clinical Implications of Azole Resistance in Aspergillus fumigatus, the Netherlands, 2007–2009
TLDR
The study found that multiazole resistance in A. fumigatus is widespread in the Netherlands and is associated with a high death rate for patients with invasive aspergillosis. Expand
Triazole Fungicides Can Induce Cross-Resistance to Medical Triazoles in Aspergillus fumigatus
TLDR
The findings support a fungicide-driven route of TR34/L98H development in Aspergillus fumigatus and have major implications for the assessment of health risks associated with the use of triazole DMIs. Expand
A New Aspergillus fumigatus Resistance Mechanism Conferring In Vitro Cross-Resistance to Azole Antifungals Involves a Combination of cyp51A Alterations
TLDR
Only transformants which had incorporated the tandem repeat in the promoter of the cyp 51A gene and the L98H amino acid substitution exhibited similarly reduced patterns of susceptibility to all triazole agents and similarly increased levels of cyp51A expression, confirming that the combination of both alterations was responsible for the azole-resistant phenotype. Expand
Aspergillus species identification in the clinical setting
TLDR
Recognising the growing role of molecular methods in species recognition, the recently convened international working group meeting entitled “Aspergillus Systematics in the Genomic Era” has proposed several recommendations that will be useful in such endeavors. Expand
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