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Antibody to SCL-70

Known as: Anti-Topoisomerase I Antibody, Anti-Topoisomerase I, Scl 70 Antibody 
An anti-nuclear autoantibody that recognizes a 70 kDa fragment of DNA topoisomerase 1. It is associated with scleroderma.
National Institutes of Health

Related topics

Related topics

7 relations
AntibodiesAntibody to Scl-70 measurementImmune System ProcessesImmune response

Papers overview

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Review
2014
Review
2014
Association of anti-RNA polymerase III autoantibodies and cancer in scleroderma
IntroductionWe assessed the profile and frequency of malignancy subtypes in a large single-centre UK cohort for patients with… 
2013
2013
The frequency of sicca symptoms and Sjögren's syndrome in patients with systemic sclerosis
The objectives are to detect the frequency of sicca symptoms and Sjögren's syndrome (SS) in patients with systemic sclerosis (SSc… 
Highly Cited
2011
Highly Cited
2011
Abnormal plasma levels of different angiogenic molecules are associated with different clinical manifestations in patients with systemic sclerosis.
OBJECTIVES Systemic Sclerosis (SSc) is characterized by a microvascular damage due to an impairment of different angiogenic and… 
2011
2011
Autoantibody response to adjuvant and nonadjuvant H1N1 vaccination in systemic lupus erythematosus
It has been reported that influenza vaccination increases autoantibody production and/or disease activity in a significant… 
Highly Cited
2008
Highly Cited
2008
Prevalence of disease-specific antinuclear antibodies in general population: estimates from annual physical examinations of residents of a small town over a 5-year period
The aim of this study was to investigate the types and prevalence of disease-specific antinuclear antibodies (ANAs) and their… 
Highly Cited
2004
Highly Cited
2004
IgG reactivity with a 100-kDa tissue and endothelial cell antigen identified as topoisomerase 1 distinguishes between limited and diffuse systemic sclerosis patients.
Review
2003
Review
2003
New insights into the pathogenesis of systemic sclerosis.
Highly Cited
2001
Highly Cited
2001
Anti-topoisomerase I (anti-Scl-70) antibodies in patients with systemic lupus erythematosus.
OBJECTIVE To investigate the presence and clinical significance of anti-Scl-70 antibodies in patients with systemic lupus… 
Highly Cited
1992
Highly Cited
1992
Association of amino acid sequences in the HLA-DQB1 first domain with antitopoisomerase I autoantibody response in scleroderma (progressive systemic sclerosis).
Previous studies in Caucasians with progressive systemic sclerosis (PSS) have suggested associations of antitopoisomerase I… 
Highly Cited
1990
Highly Cited
1990
Autoantibodies to topoisomerase I (Scl-70): analysis by gel diffusion, immunoblot, and enzyme-linked immunosorbent assay.
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