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Anti-CD70 Antibody-drug Conjugate SGN-CD70A

Known as: SGN-CD70A 
An antibody-drug conjugate (ADC) containing an engineered cysteine monoclonal antibody (EC-mAb), directed against the extracellular domain of the… 
National Institutes of Health

Related topics

Related topics

1 relation
antigen binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Abstract 2688: SGN-CD228A: A novel humanized anti-CD228 antibody-drug conjugate for the treatment of solid tumors
Melanotransferrin (CD228/MFI2/MELTF) is a cell-surfaced glycosylphosphatidylinoitol (GPI)-anchored glycoprotein that belongs to… 
Review
2017
Review
2017
Abstract 4589: Preclinical investigation of SGN-CD70A antibody-drug conjugate in T cell lymphomas
CD70 is a member of the tumor necrosis factor (TNF) superfamily and aberrantly expressed in several solid tumors and a variety of… 
2016
2016
Abstract 2966: Preclinical combinations of the antibody-drug conjugate SGN-LIV1A with chemotherapies show increased activity
SGN-LIV1A is an antibody-drug conjugate (ADC) currently being evaluated in a phase 1 clinical trial for metastatic breast cancer… 
2016
2016
Abstract 4778: Covalent bonding of a C8-conjugated pyrrolobenzodiazepine (PBD) monomer and dimer to a terminal guanine residue of DNA duplex and hairpin fragments
The pyrrolobenzodiazepines (PBDs) are a family of covalent-binding DNA-interactive minor-groove binding agents that are of… 
Review
2015
Review
2015
Targeting LSCs through membrane antigens selectively or preferentially expressed on these cells.
2015
2015
Abstract 2541: Preclinical results of SGN-CD19A in combination with R-ICE or R-CHOP in non-Hodgkin lymphoma models
Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA SGN-CD19A is an antibody drug conjugate (ADC… 
2015
2015
Abstract 1686: CD70 as a target in non-Hodgkin lymphoma (NHL) and renal cell carcinoma (RCC)
Background CD70 is a member of the TNF superfamily expressed primarily on activated lymphocytes. CD70 interacts with CD27 to… 
2014
2014
Abstract DDT01-04: SGN-CD19A: A novel Anti-CD19 antibody drug conjugate
CD19, a member of the immunoglobulin superfamily, is a B-cell specific marker that is found on B cells as early as the pro-B cell… 
2014
2014
Abstract 4642: Model-based alternative clinical trial designs and evaluations for SGN-CD19A, a novel antibody-drug conjugate
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Background SGN-CD19A is a novel antibody-drug conjugate… 
2013
2013
A First-In-Human Phase 1 Study Of The Antibody-Drug Conjugate SGN-CD19A In Relapsed Or Refractory B-Lineage Acute Leukemia and Highly Aggressive Lymphoma
Background CD19, a member of the immunoglobulin superfamily, is a B-cell specific marker that is found on B cells as early as the… 
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